THE PREPARATION OF A NEW PROTEIN BASED HPLC COLUMN PACKING MATERIAL AND ENANTIOMERIC RESOLUTION OF SOME PHARMACEUTICAL RELATED COMPOUNDS VIA THIS COLUMN

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dc.contributor.authorErdoğan, Ömer
dc.contributor.authorTopal, Giray
dc.contributor.authorÇakmak, Reşit
dc.contributor.authorSünkür, Murat
dc.contributor.authorCanpolat, Mutlu
dc.date.accessioned2025-03-08T18:29:19Z
dc.date.available2025-03-08T18:29:19Z
dc.date.issued2016
dc.departmentDicle Üniversitesi
dc.description.abstractIn this study, BSA was bounded to 3-chloropropyl functionalized silica gel via ethylenediamine and glutaric dialdehyde. The prepared CSP was packed into 150X4.6mm HPLC column according to slurry method. The enantiomeric resolution of some pharmaceutical related compounds such as rac-mandelic acid, rac-methyl mandelate, rac-epinephrine, rac-propranolol, rac-?-phenylethylamine and rac-3-hydroxybutyric acid was employed in 1mL/rpm, 1,5mL/rpm, 2mL/rpm, 2,5mL/rpm, 3mL/rpm flow rate in various pHs such pH=6, pH=7, pH=8 0,1M phosphate buffer. Chromatographic parameters such as Rs and ? were calculated for each resoluted compounds.
dc.identifier.doi10.23884/mejs/2016.2.1.07
dc.identifier.endpage92
dc.identifier.issn2618-6136
dc.identifier.issue1
dc.identifier.startpage77
dc.identifier.urihttps://doi.org/10.23884/mejs/2016.2.1.07
dc.identifier.urihttps://hdl.handle.net/11468/31769
dc.identifier.volume2
dc.language.isoen
dc.publisherBilal GÜMÜŞ
dc.relation.ispartofMiddle East Journal of Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_21250205
dc.subjectEnantiomeric separation
dc.subjecthplc
dc.subjectbovine serum albumin
dc.titleTHE PREPARATION OF A NEW PROTEIN BASED HPLC COLUMN PACKING MATERIAL AND ENANTIOMERIC RESOLUTION OF SOME PHARMACEUTICAL RELATED COMPOUNDS VIA THIS COLUMN
dc.typeArticle

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