New Voltammetric Approach to the Quantitation of Paracetamol in Tablets and Syrup using Chemometric Optimization Technique

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dc.contributor.authorGuzel, Remziye
dc.contributor.authorEksi, Haslet
dc.contributor.authorDinc, Erdal
dc.contributor.authorSolak, Ali Osman
dc.date.accessioned2024-04-24T17:11:54Z
dc.date.available2024-04-24T17:11:54Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractA new voltammetric approach was developed for the determination of paracetamol in tablet and syrup samples using chemometric optimization. The method is based on the use of the gold nanoparticles-polyaniline (AuNPs-PA) modified pencil graphite electrode (PGE). Electrode system was fabricated by using the electrochemical reduction of gold on aniline modified pencil electrode to give gold nanoparticles. A 3(3) full factorial design was used to find optimal oxidation conditions of paracetamol on the AuNPs-PA-PGE. The optimal oxidation conditions of drug substance were found as -524 mV for the accumulation potential, 295 s for the accumulation time and pH 8.69 (for the phosphate buffer solution, 0.1 M). The determination of paracetamol was linear in the range of 2.0 x 10(-7)-6.0 x 10(-6) M with a detection limit of 5 x 10(-8) M. As a result, the proposed voltammetric approach gave satisfactory results for the determination of the related drug substance in tablets and syrup.en_US
dc.description.sponsorshipAnkara University [10A3336001]en_US
dc.description.sponsorshipThis work was done within the Chemometric Laboratory of Faculty of Pharmacy and it was supported by the scientific research project no. 10A3336001 of Ankara University.en_US
dc.identifier.doi10.1134/S1061934819030110
dc.identifier.endpage305en_US
dc.identifier.issn1061-9348
dc.identifier.issn1608-3199
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85064265007en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage296en_US
dc.identifier.urihttps://doi.org/10.1134/S1061934819030110
dc.identifier.urihttps://hdl.handle.net/11468/17772
dc.identifier.volume74en_US
dc.identifier.wosWOS:000464875600011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherPleiades Publishing Incen_US
dc.relation.ispartofJournal of Analytical Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExperimental Design And Optimizationen_US
dc.subjectGold Nanoparticlesen_US
dc.subjectParacetamolen_US
dc.subjectPencil Graphite Electrodeen_US
dc.titleNew Voltammetric Approach to the Quantitation of Paracetamol in Tablets and Syrup using Chemometric Optimization Techniqueen_US
dc.typeArticleen_US

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