Human Placental Macrophages (Hofbauer Cells) in Severe Preeclampsia Complicated by HELLP Syndrome Immunohistochemistry of Chorionic Villi

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dc.contributor.authorEvsen, Mehmet Siddik
dc.contributor.authorKalkanli, Sevgi
dc.contributor.authorDeveci, Engin
dc.contributor.authorSak, Muhammet Erdal
dc.contributor.authorOzler, Ali
dc.contributor.authorBaran, Ozlem
dc.contributor.authorErdem, Elif
dc.date.accessioned2024-04-24T17:44:34Z
dc.date.available2024-04-24T17:44:34Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To evaluate Hofbauer cells in the placentas of women diagnosed with HELLP syndrome. STUDY DESIGN: The present study compared 20 patients with HELLP syndrome and 20 control patients with respect to demographics, hematological parameters and the presence of Hofbauer cells in placental samples. CD-68 antibody was used for immunohistochemical examination. The total number and size of Hofbauer cells were measured in the placental villi, and the proportion of Hofbauer cells relative to the vascular structure was also compared between groups. RESULT: The patient and control groups were similar according to baseline obstetric characteristics. White blood cell counts in patients with HELLP syndrome and the control group were 15,139 4,169 and 10,806 2,888, respectively, and were significantly increased among patients with HELLP syndrome (p < 0.001). Hofbauer cell numbers in the placental villi of patients with HELLP syndrome were significantly elevated in comparison to normotensive controls (p = 0.046). The proportion of Hofbauer cells in the placental villi according to proximity to the vascular structure were 3.85 +/- 1.66 in the HELLP group and 1.75 +/- 1.12 in controls (p < 0.001). Sizes of the Hofbauer cells were not statistically different between groups. CONCLUSION: Increased Hofbauer cells may be associated with increased inflammation or may have an adaptive mechanism at the fetal site of the placenta in patients with HELLP syndrome.en_US
dc.identifier.endpage288en_US
dc.identifier.issn0884-6812
dc.identifier.issue5en_US
dc.identifier.pmid24282909
dc.identifier.startpage283en_US
dc.identifier.urihttps://hdl.handle.net/11468/22159
dc.identifier.volume35en_US
dc.identifier.wosWOS:000326423000007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytology and Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHellp Syndromeen_US
dc.subjectHofbauer Cellsen_US
dc.subjectMacrophagesen_US
dc.subjectPlacentaen_US
dc.subjectPreeclampsiaen_US
dc.titleHuman Placental Macrophages (Hofbauer Cells) in Severe Preeclampsia Complicated by HELLP Syndrome Immunohistochemistry of Chorionic Villien_US
dc.titleHuman Placental Macrophages (Hofbauer Cells) in Severe Preeclampsia Complicated by HELLP Syndrome Immunohistochemistry of Chorionic Villi
dc.typeArticleen_US

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