Exploring 18F-FDG uptake patterns in liver, spleen, and bone marrow: Implications for inflammatory and infectious conditions

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dc.contributor.authorTuzcu, Şadiye Altun
dc.contributor.authorÇetinkaya, Erdal
dc.contributor.authorGÇzel, Fatih
dc.contributor.authorÇetin, İlbey Erkin
dc.contributor.authorMete, Ümit
dc.contributor.authorArgın, Eşref
dc.contributor.authorTaşdemir, Bekir
dc.date.accessioned2025-02-22T14:10:55Z
dc.date.available2025-02-22T14:10:55Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: This study aimed to explore the relationship between fluorine-18-fluorodeoxyglucose (18F-FDG) uptake in the liver, spleen, and bone marrow and inflammatory markers such as c-reactive protein (CRP), albumin, and erythrocyte sedimentation rate (ESR) in patients undergoing positron emission tomography/computed tomography (PET/CT) imaging for cancer diagnosis. SUBJECTS AND METHODS: This retrospective cross-sectional study included a total of 708 patients with a diagnosis of malignancy. Fluorine-18-FDG PET/CT images acquired between January 2021 and December 2022. Exclusion criteria comprised prior chemotherapy, radiotherapy, hematological malignancies, or liver/spleen tumors. Statistical analysis included correlation analysis, univariate, and multivariate regression analysis. RESULTS: C-reactive protein levels demonstrated a significant positive correlation with 18F-FDG uptake in the spleen (r=0.104, P=0.006) and bone marrow (r=0.112, P=0.003). Albumin showed a negative correlation with liver 18F-FDG uptake (r=-0.220, P<0.001). Regression analysis revealed ESR's impact on spleen-to-liver (P=0.023) and bone marrow-to-liver (P=0.012) 18F-FDG uptake. CONCLUSION: This study demonstrates the association between inflammatory markers and 18F-FDG uptake in liver, spleen and bone marrow. C-reactive protein and ESR showing significant correlations with spleen and bone marrow 18F-FDG uptake, and albumin correlated with liver 18F-FDG uptake negatively. Erythrocyte sedimentation rate had significant impact on spleen and bone marrow 18F-FDG uptakes. These findings suggest the potential of 18F-FDG PET/CT in diagnosing inflammatory conditions, warranting further investigation into its clinical implications.en_US
dc.identifier.doi10.1967/s002449912752
dc.identifier.endpage187en_US
dc.identifier.issn1790-5427
dc.identifier.issue3en_US
dc.identifier.pmid39644269en_US
dc.identifier.scopus2-s2.0-85214319102en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage181en_US
dc.identifier.urihttps://doi.org/10.1967/s002449912752
dc.identifier.urihttps://hdl.handle.net/11468/29893
dc.identifier.volume27en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofHellenic journal of nuclear medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_Scopus_20250222
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectBiological Transporten_US
dc.subjectBone Marrowen_US
dc.subjectCross-Sectional Studiesen_US
dc.subjectFemaleen_US
dc.subjectFluorodeoxyglucose F18en_US
dc.subjectHumansen_US
dc.subjectInfectionsen_US
dc.subjectInflammationen_US
dc.subjectLiveren_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectPositron Emission Tomography Computed Tomographyen_US
dc.subjectRetrospective Studiesen_US
dc.subjectSpleenen_US
dc.subjectfluorodeoxyglucose f 18en_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectbone marrowen_US
dc.subjectcross-sectional studyen_US
dc.subjectdiagnostic imagingen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectinfectionen_US
dc.subjectinflammationen_US
dc.subjectliveren_US
dc.subjectmaleen_US
dc.subjectmetabolismen_US
dc.subjectmiddle ageden_US
dc.subjectpositron emission tomography-computed tomographyen_US
dc.subjectretrospective studyen_US
dc.subjectspleenen_US
dc.subjecttransport at the cellular levelen_US
dc.subjectvery elderlyen_US
dc.titleExploring 18F-FDG uptake patterns in liver, spleen, and bone marrow: Implications for inflammatory and infectious conditionsen_US
dc.typeArticleen_US

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