EVALUATION OF TPEAK-TEND INTERVAL AND TPEAK-END/QT RATIO IN PATIENTS WITH SARCOIDOSIS

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dc.contributor.authorUcsular, Fatma
dc.contributor.authorKaradeniz, Gulistan
dc.contributor.authorKaradeniz, Cem
dc.contributor.authorYalniz, Enver
dc.contributor.authorDemir, Melike
dc.date.accessioned2024-04-24T17:48:07Z
dc.date.available2024-04-24T17:48:07Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Tp-e interval which represents the interval between the peak and the end of the T-wave on electrocardiogram (ECG), can be used as a marker of transmural dispersion of repolarization. Also, Tp-e/QT and Tp-e/QTc ratios are used as an index of arrhythmogenesis. Prolonged Tp-e interval and Tp-e/QT ratio was found associated with sudden cardiac death in different clinical conditions. Novel ventricular repolarization parameters, Tp-e interval, Tp-e/QT and Tp-e/QTc ratios have not been evaluated in patients with sarcoidosis without cardiac symptoms previously. Therefore, we investigated Tp-e interval in patients with pulmonary sarcoidosis. Methods: Sixty-one consecutive patients diagnosed with biopsy-proven pulmonary sarcoidosis were retrospectively reviewed. The 12-lead ECG examinations were performed at speed of 25 mm/s while the patients were in supine position. QT dispersion, Tp-e intervals and Tp-e/QT ratio were measured. Results: Comparison of ECG parameters between two groups showed a significantly higher average heart rate (p<0.05) in the patients with sarcoidosis than controls. QT dispersion was higher in patients group. Tp-e interval was significantly prolonged in the study group compared to the control group (92+/-21 ms and 85+/-14 ms, respectively; p<0.05). Tp-e/QT and Tp-e/QTc ratios were significantly higher in patients with sarcoidosis compared to control subjects (all p values < 0.05). Conclusions: The novel repolarization parameters Tp-e interval, Tp-e/QT and Tp-e/QTc ratios are increased in patients with sarcoidosis without any cardiac symptoms. These parameters might be used as a marker for predicting the ventricular arrhythmias and sudden cardiac death in patients with sarcoidosis.en_US
dc.identifier.endpage156en_US
dc.identifier.issn1124-0490
dc.identifier.issue2en_US
dc.identifier.pmid27537718
dc.identifier.startpage151en_US
dc.identifier.urihttps://hdl.handle.net/11468/22893
dc.identifier.volume33en_US
dc.identifier.wosWOS:000393272500008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMattioli 1885en_US
dc.relation.ispartofSarcoidosis Vasculitis and Diffuse Lung Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectrocardiogramen_US
dc.subjectSarcoidosisen_US
dc.subjectTpeak-Tend Intervalen_US
dc.subjectTp-E/Qt Ratioen_US
dc.titleEVALUATION OF TPEAK-TEND INTERVAL AND TPEAK-END/QT RATIO IN PATIENTS WITH SARCOIDOSISen_US
dc.titleEVALUATION OF TPEAK-TEND INTERVAL AND TPEAK-END/QT RATIO IN PATIENTS WITH SARCOIDOSIS
dc.typeArticleen_US

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