Carvacrol prevents methotrexateinduced renal oxidative injury and renal damage in rats

Basit Öğe Kaydı
dc.contributor.authorBozkurt M.
dc.contributor.authorEm S.
dc.contributor.authorOktayoglu P.
dc.contributor.authorTurkcu G.
dc.contributor.authorYuksel H.
dc.contributor.authorSariyildiz M.A.
dc.contributor.authorCaglayan M.
dc.date.accessioned2024-04-24T18:46:06Z
dc.date.available2024-04-24T18:46:06Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: The purpose of this study was to investigate the effect of carvacrol (CAR) on methotrexate (MTX)-induced renal damage in rats. Methods: Twenty-four male rats were equally divided into three groups: group I, control treatment; group II, MTX-treated; and group III, MTX+CAR-treated. A single dose of CAR (73 mg/kg) was administered intraperitoneally to group III on the First day of the experiment and a single dose of MTX (20 mg/kg) was administered intraperitoneally to groups II and III on the second day of the experiment. Blood samples and kidney tissue were obtained from each animal on day 8 for the measurement of malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI). Light microscopy was used for histopathological examination of kidney specimens. Results: MDA, TOS and OSI levels were significantly greater in the group receiving MTX alone relative to the control animals, while the TAS level was significantly reduced in the MTX group compared with the control group. The administration of CAR was associated with significantly decreased MDA, TOS, and OSI levels and increased TAS levels relative to the rats treated with MTX alone. Animals treated with CAR exhibited decreased tubular degeneration and architectural impairment relative to animals treated with MTX alone; however, the difference in histological scores did not meet the threshold of statistical significance. Conclusions: MTX treatment results in oxidative damage to the rat kidney; damage which is partially abrogated by the administration of CAR. © 2014 CIM.en_US
dc.identifier.endpageE25en_US
dc.identifier.issn0147-958X
dc.identifier.issue1en_US
dc.identifier.pmid24502808
dc.identifier.scopus2-s2.0-84894078752
dc.identifier.scopusqualityQ2
dc.identifier.startpageE19en_US
dc.identifier.urihttps://hdl.handle.net/11468/25063
dc.identifier.volume37en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofClinical and Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleCarvacrol prevents methotrexateinduced renal oxidative injury and renal damage in ratsen_US
dc.titleCarvacrol prevents methotrexateinduced renal oxidative injury and renal damage in rats
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu