Effects of systemic zoledronic acid administration on osseointegration of hydroxyapatite-coated and resorbable blast material surface implants in rabbit models

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dc.contributor.authorYaman F.
dc.contributor.authorAğaçayak S.
dc.contributor.authorAtilgan S.
dc.contributor.authorBenlidayi E.
dc.contributor.authorUcan M.C.
dc.contributor.authorErol B.
dc.contributor.authorKaya B.
dc.date.accessioned2024-04-24T18:45:51Z
dc.date.available2024-04-24T18:45:51Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: It is unknown whether zoledronic acid (ZA) interferes with initial bone healing at implant sites. The goal of this study was to examine the effects of systemic zoledronic acid administration on osseintegration of hydroxyapatite (HA)-coated and resorbable blast material surface (RBM) implants in rabbit models. Materials and Methods: Twenty-eight male New Zealand rabbits (aged 6 to 12 months) were used in this study. Rabbits were randomly assigned to four groups. In group A, HA-coated implants were placed in the right tibia of seven rabbits. In group B, RBM-surface implants were placed in the right tibia of seven rabbits. In group C, HA-coated implants were placed in seven rabbits with intravenous (IV) administration of ZA. Finally, in group D, RBM-surface implants were placed in seven rabbits with IV administration of ZA. For groups C and D, IV zoledronic acid (0.1 mg/kg) was performed monthly during the entire osseointegration period. All of the rabbits were sacrificed 12 weeks after the implantation, and tibial specimens were harvested. Histomorphometric boneto- implant contact (BIC) analysis and the data were statistically analyzed. Results: The highest BIC percentage was detected in group D, with a mean value of 56.73% ± 1.85%, as compared with 45.80% ± 3.77% in group C, 35.11% ± 0.76% in group B, and 31.14% ± 1.04% in group A. Conclusions: Histomorphometric analyses showed significant improvement in the osseointegration of implants in the RBM-surface ZA group compared with the HA-coated ZA group. The results of this study suggest that systemic ZA administration may improve osseointegration of titanium implants in bone. © 2012 by Quintessence Publishing Co Inc.en_US
dc.identifier.endpage1447en_US
dc.identifier.issn0882-2786
dc.identifier.issue6en_US
dc.identifier.pmid23189295
dc.identifier.scopus2-s2.0-84880165548
dc.identifier.scopusqualityQ2
dc.identifier.startpage1443en_US
dc.identifier.urihttps://hdl.handle.net/11468/24923
dc.identifier.volume27en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Implants
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHistomorphometryen_US
dc.subjectImplanten_US
dc.subjectZoledronic Aciden_US
dc.titleEffects of systemic zoledronic acid administration on osseointegration of hydroxyapatite-coated and resorbable blast material surface implants in rabbit modelsen_US
dc.titleEffects of systemic zoledronic acid administration on osseointegration of hydroxyapatite-coated and resorbable blast material surface implants in rabbit models
dc.typeArticleen_US

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