Alchemilla pseudocartalinica Juz: Phytochemical screening by UPLC-MS/MS, molecular docking, anti-oxidant, anti-diabetic, anti-glaucoma, and anti-alzheimer effects

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dc.authorid0000-0002-4090-7227en_US
dc.contributor.authorGüven, Leyla
dc.contributor.authorErtürk, Adem
dc.contributor.authorAlwasel, Saleh
dc.contributor.authorGülçin, İlhami
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.date.accessioned2024-03-21T08:10:26Z
dc.date.available2024-03-21T08:10:26Z
dc.date.issued18.03.2024en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractAlchemilla species (Rosaceae) are popularly known as 'Lady's Mantle, Lion's claw' and are used for medicinal purposes as diuretic, laxative, tonic, and wound healing agents. Bioactivities and phenolic content of Alchemilla pseudocartalinica Juz. species have yet to be investigated. Our research focused on assessing the antioxidant characteristics of A. pseudocartalinica methanol (MEAP) and water extracts (WEAP), as well as their inhibitory effects on acetylcholinesterase (AChE), alpha-glycosidase (alpha-gly), and human carbonic anhydrase II (hCA II) enzymes. Additionally, we conducted chemical characterization using UPLC-MS/MS and investigated the correlation between major phenolic compounds and enzymes through molecular docking analysis. To assess the antioxidant activities of the MEAP and WEAP, six test systems were employed, including DPPH, ABTS, DMPD, FRAP, CUPRAC, and Fe3+ reducing assays. The outcome showed that the methanol extract of the plant generally has stronger antioxidant activity. In addition, UPLC-MS/MS analysis indicated, miquelianin (44.095 mg/g), quinic acid (17.054 mg/g), and ellagic acid (6.492 mg/g) were significant in the methanol extract. A molecular docking study revealed a significant affinity for binding between the hCAII enzyme and quinic acid, miquelianin, and AChE/alpha-gly enzymes. A. pseudocatalinica methanol and water extracts have high antioxidant activity and good inhibition effect against AChE, alpha-glycosidase, and hCA II enzymes.en_US
dc.identifier.citationGüven, L., Ertürk, A., Yılmaz, M. A., Alwasel, S. H., & Gülçin, L. (2024, March 9). Alchemilla pseudocartalinica juz: Phytochemical screening by UPLC-MS/MS, molecular docking, anti-oxidant, anti-diabetic, anti-glaucoma, and anti-alzheimer effects. Records of Natural Products, 1–22. https://doi.org/10.25135/rnp.448.2312.2993. Early access.en_US
dc.identifier.doi10.25135/rnp.448.2312.2993
dc.identifier.endpage22en_US
dc.identifier.issn1307-6167
dc.identifier.scopus2-s2.0-85188929453
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.acgpubs.org/doc/20240309093957448-RNP-2312-2993.pdf
dc.identifier.urihttps://hdl.handle.net/11468/13665
dc.identifier.volumeEarly Accessen_US
dc.identifier.wosWOS:001182264700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherACG Publicationsen_US
dc.relation.ispartofRecords of Natural Products
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlchemillaen_US
dc.subjectUPLC-MS/MSen_US
dc.subjectAntioxidant activityen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectMolecular dockingen_US
dc.titleAlchemilla pseudocartalinica Juz: Phytochemical screening by UPLC-MS/MS, molecular docking, anti-oxidant, anti-diabetic, anti-glaucoma, and anti-alzheimer effectsen_US
dc.titleAlchemilla pseudocartalinica Juz: Phytochemical screening by UPLC-MS/MS, molecular docking, anti-oxidant, anti-diabetic, anti-glaucoma, and anti-alzheimer effects
dc.typeArticleen_US

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