Evaluation of erythroprotein effects on cerebral ischemia in rats

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dc.contributor.authorAluclu, Mehmet Ufuk
dc.contributor.authorAcar, Abdullah
dc.contributor.authorGuzel, Aslan
dc.contributor.authorBahceci, Selen
dc.contributor.authorYaldiz, Mehmet
dc.date.accessioned2024-04-24T17:44:32Z
dc.date.available2024-04-24T17:44:32Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Majority of severe disabilities in adults are caused by stroke. The aim of our study is to learn the effects of erythropoietin (EP), on infarct size in cerebral ischemia and to determine neurological behavioral scores and histopathological evaluation. Material & Methods: In this study 30 adult Sprague-Dawney rats were used. Cerebral ischemia was constituted by intraluminal filament method with a 4-0- nylon suture. Reperfusion was started after two hours of middle cerebral artery occlusion. The rats were randomly divided into two groups as follow: control and EPO groups. Saline 0.9% (0.5 ml/kg) and EPO (5000 U/kg) was administered intraperitoneally in the groups. Three coronal slices in two millimeters thickness were obtained from cerebrum, cerebellum and brain stem, and were stained with a 2% solution of triphenyltetrazolium chloride. Transparent sheets were placed over each section and the areas of the brain and infarct were measured. The neurological scores were determined at 24(th), 48(th) and 72(nd) hours after reperfusion. Results: Percent of ischemic area (%) in cerebrum, cerebellum and brain stem level in EPO groups were less than those of control group (p<0.0001). In addition, we determined that EPO group was better than controls of neurologic score and histopatologically after cerebral ischemia. Conclusions: We concluded that EPO may decrease ischemic area in experimental cerebral ischemia in rats and it seems that EPO may be beneficial.en_US
dc.identifier.endpage174en_US
dc.identifier.issn0172-780X
dc.identifier.issn2354-4716
dc.identifier.issue2en_US
dc.identifier.pmid17435667
dc.identifier.startpage170en_US
dc.identifier.urihttps://hdl.handle.net/11468/22140
dc.identifier.volume28en_US
dc.identifier.wosWOS:000246249800014
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMaghira & Maas Publicationsen_US
dc.relation.ispartofNeuroendocrinology Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectErythropoietinen_US
dc.subjectExperimental Cerebral Ischemiaen_US
dc.titleEvaluation of erythroprotein effects on cerebral ischemia in ratsen_US
dc.titleEvaluation of erythroprotein effects on cerebral ischemia in rats
dc.typeArticleen_US

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