Aquaporin 1, Aquaporin 3 and Aquaporin 5 expression and EGFR mutation in malignant pleural mesotheliomas: an imunohistochemical and molecular study

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dc.contributor.authorAlabalik, Ulas
dc.contributor.authorTurkcu, Gul
dc.contributor.authorKeles, Ayse Nur
dc.contributor.authorIbiloglu, Ibrahim
dc.contributor.authorUrakci, Zuhat
dc.contributor.authorBuyukbayram, Huseyin
dc.date.accessioned2024-04-24T17:07:45Z
dc.date.available2024-04-24T17:07:45Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractMalignant pleural mesothelioma is a rare and fatal malignancy. This disease is, unfortunately, at its advanced stage when it is diagnosed. Survival time is usually not more than a few months. The aim of this study was to analyse the expression of Aquaporin 1, Aquaporin 3 and Aquaporin 5 in malignant pleural mesotheliomas and to explore the relationship of these levels of expression with epidermal growth factor receptor (EGFR) gene mutation and prognostic parameters. In this study, 60 cases diagnosed as malignant pleural mesothelioma among the pleural biopsy materials in the archives of the Pathology Department of Medical Faculty of Dicle University in 2003-2013 were evaluated. The tissues were stained immunohistochemically with antibodies against Aquaporin 1, Aquaporin 3 and Aquaporin 5, and the existence of EGFR mutation was investigated in the tissues by real-time polymerase chain reaction (PCR). The obtained results showed expression of Aquaporin 1, Aquaporin 3 and Aquaporin 5 in varied amounts in malignant pleural mesotheliomas. However, no significant relation was obtained thus far between the expression levels of these aquaporins and the prognostic parameters. No mutations were detected in the EGFR gene exons 18-21 by using real-time PCR. It could be suggested that although Aquaporin 1, Aquaporin 3 and Aquaporin 5 are expressed in malignant pleural mesothelioma, they do not have any effect on the prognostic parameters. Mutations in different domains of EGFR gene, other than exons 18-21, should be sought to develop new targeted treatments.en_US
dc.description.sponsorshipDicle University Scientific Research Projects Coordination Unit (DUBAP) [14-TF-56]; Dicle Universitesi [14-TF-56]en_US
dc.description.sponsorshipThis study was supported by Dicle University Scientific Research Projects Coordination Unit (DUBAP) [grant number 14-TF-56]; Dicle Universitesi [grant number 14-TF-56].en_US
dc.identifier.doi10.1080/13102818.2016.1264275
dc.identifier.endpage372en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85006173674
dc.identifier.scopusqualityQ3
dc.identifier.startpage367en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2016.1264275
dc.identifier.urihttps://hdl.handle.net/11468/16957
dc.identifier.volume31en_US
dc.identifier.wosWOS:000399341000020
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMalignant Pleural Mesotheliomaen_US
dc.subjectAquaporinen_US
dc.subjectEgfren_US
dc.subjectPcren_US
dc.subjectTarget Treatmenten_US
dc.titleAquaporin 1, Aquaporin 3 and Aquaporin 5 expression and EGFR mutation in malignant pleural mesotheliomas: an imunohistochemical and molecular studyen_US
dc.titleAquaporin 1, Aquaporin 3 and Aquaporin 5 expression and EGFR mutation in malignant pleural mesotheliomas: an imunohistochemical and molecular study
dc.typeArticleen_US

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