Urinary expression of acute kidney injury biomarkers in patients after RIRS: it is a prospective, controlled study

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dc.contributor.authorDede, Onur
dc.contributor.authorDagguli, Mansur
dc.contributor.authorUtangac, Mazhar
dc.contributor.authorYuksel, Hatice
dc.contributor.authorBodakci, Mehmet Nuri
dc.contributor.authorHatipoglu, Namik Kemal
dc.contributor.authorSancaktutar, Ahmet Ali
dc.date.accessioned2024-04-24T17:40:13Z
dc.date.available2024-04-24T17:40:13Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To evaluated the damage effects of retrograde intra-renal surgery (RIRS) on kidney tissue by measuring kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-Dglucosaminidase (NAG), liver-type fatty acid binding protein (LFABP) expression. Material and methods: We enrolled thirty consecutive patients (Group 1) who underwent RIRS that presented with renal calculi size <2 cm. Forty-seven control patients (Group 2) with no signs or symptoms of urogenital disease were also enrolled for this study. Patients urine KIM-1, NGAL, NAG, and LFABP and creatinine levels were determined before the surgery, 2 hours after the surgery, and 24 hours after the surgery. Results: Demographic data were established and found to be similar between the two groups. Two hours after the surgery KIM-1/Cr and NGAL/Cr levels had increased significantly in urine compared to levels before the surgery (P:0.04, P:0.02 respectively) and decreased 24 hours after the surgery. The NAG/Cr and LFABP/Cr levels did not change significantly after the surgery. Conclusion: According to acute kidney injury (AKI) markers, this study is suggests that RIRS is a safe method, KIM-1/Cr and NGAL/Cr levels were increased first 2 hours but returned to initial levels within 24 hours after the surgery.en_US
dc.identifier.endpage8152en_US
dc.identifier.issn1940-5901
dc.identifier.issue5en_US
dc.identifier.pmid26221383
dc.identifier.startpage8147en_US
dc.identifier.urihttps://hdl.handle.net/11468/21686
dc.identifier.volume8en_US
dc.identifier.wosWOS:000359293200183
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRetrograde Intra-Renal Surgeryen_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectKidney Injury Molecule-1en_US
dc.subjectNeutrophil Gelatinase-Associated Lipocalinen_US
dc.subjectN-Acetyl-Beta-D-Glucosaminidaseen_US
dc.titleUrinary expression of acute kidney injury biomarkers in patients after RIRS: it is a prospective, controlled studyen_US
dc.titleUrinary expression of acute kidney injury biomarkers in patients after RIRS: it is a prospective, controlled study
dc.typeArticleen_US

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