Efficacy of pemetrexed plus a platinum rechallenge in the treatment of pleural mesothelioma

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dc.authorid0000-0003-3878-988Xen_US
dc.authorid0000-0002-0878-6525en_US
dc.authorid0000-0002-7931-2941en_US
dc.authorid0000-0001-7858-8180en_US
dc.authorid0000-0003-0882-0524en_US
dc.authorid0000-0001-7336-871Xen_US
dc.authorid0000-0002-7451-7286en_US
dc.contributor.authorUrakçı, Zuhat
dc.contributor.authorEbinç, Senar
dc.contributor.authorOruç, Zeynep
dc.contributor.authorKalkan, Ziya
dc.contributor.authorKaplan, Muhammet Ali
dc.contributor.authorKüçüköner, Mehmet
dc.contributor.authorIşıkdoğan, Abdurrahman
dc.date.accessioned2024-03-04T06:56:04Z
dc.date.available2024-03-04T06:56:04Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractIntroduction. Pemetrexed-based rechallenge therapies can be used as an option in the treatment of pleural mesothelioma. We aimed to investigate the efficacy of pemetrexed-based rechallenge in mesothelioma. Material and methods. A total of 132 patients who received chemotherapy for unresectable or metastatic pleural mesothelioma in the Medical Oncology Clinic of Dicle University Medical Faculty between 2005 and 2020 were included in our study. Pemetrexed plus platinum rechallenge treatments were compared with other chemotherapy regimens in terms of survival. Results. In our study, 31 (23.4%) of a total of 132 patients received rechallenge pemetrexed plus platinum treatment. There was no statistically significant difference between median progression-free survival of patients who received pemetrexed plus cisplatin or gemcitabine plus cisplatin in the first-line therapy [5 months vs. 8 months (HR = 1.43; 95% CI 0.59–3.45; p = 0.376)]. In the second-line treatment, patients who received rechallenge pemetrexed plus platinum therapy had statistically significantly higher median PFS than those who received gemcitabine plus platinum [6 months vs. 4 months (HR = 0.46; 95% CI 0.22–0.94; p = 0.011)] due to a previous good response. In the second-line treatment, median overall survival was 15 months with gemcitabine plus platinum and 29 months with pemetrexed plus platinum rechallenge (p = 0.007). Conclusions. This study demonstrated that the pemetrexed plus platinum regimen was more effective than gemcitabine plus platinum in the second-line treatment in terms of both progression-free and overall survival in patients who had previously benefited from pemetrexed-based chemotherapy and had not progressed up to 6 months after first-line treatment.en_US
dc.identifier.citationUrakçı, Z., Ebinç, S., Oruç, Z., Kalkan, Z., Kaplan, M. A., Küçüköner, M. ve diğerleri. (2023). Efficacy of pemetrexed plus a platinum rechallenge in the treatment of pleural mesothelioma. Oncology in Clinical Practice, 19(4), 224-234.en_US
dc.identifier.doi10.5603/OCP.2023.0014
dc.identifier.endpage234en_US
dc.identifier.issn2450-1654
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85173705290
dc.identifier.scopusqualityQ4
dc.identifier.startpage224en_US
dc.identifier.urihttps://journals.viamedica.pl/oncology_in_clinical_practice/article/view/OCP.2023.0014
dc.identifier.urihttps://hdl.handle.net/11468/13476
dc.identifier.volume19en_US
dc.identifier.wosWOS:001065396100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorUrakçı, Zuhat
dc.institutionauthorEbinç, Senar
dc.institutionauthorOruç, Zeynep
dc.institutionauthorKalkan, Ziya
dc.institutionauthorKaplan, Muhammet Ali
dc.institutionauthorKüçüköner, Mehmet
dc.institutionauthorIşıkdoğan, Abdurrahman
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofOncology in Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPemetrexeden_US
dc.subjectPleural mesotheliomaen_US
dc.subjectRechallengeen_US
dc.titleEfficacy of pemetrexed plus a platinum rechallenge in the treatment of pleural mesotheliomaen_US
dc.titleEfficacy of pemetrexed plus a platinum rechallenge in the treatment of pleural mesothelioma
dc.typeArticleen_US

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