Effects of Systemic Propranolol Application on the New Bone Formation in Periimplant Guided Bone Regeneration

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dc.contributor.authorGunes, Nedim
dc.contributor.authorGul, Mehmet
dc.contributor.authorDundar, Serkan
dc.contributor.authorArtas, Gokhan
dc.contributor.authorKobat, Mehmet Ali
dc.contributor.authorTekin, Samet
dc.contributor.authorBozoglan, Alihan
dc.date.accessioned2024-04-24T17:24:50Z
dc.date.available2024-04-24T17:24:50Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: The aim of this experimental animal study was to evaluate the effects of systemic propranolol on new bone formation in peri-implant bone defects. Material and Methods: Implant slots were created 4 mm long and 2.5 mm wide. After the titanium implants were placed in the sockets, 2 mm defects were created in the neck of the implants. Bone grafts were placed in these defects. Then the rats were randomly divided into three equal groups: control (n = 8), propranolol dose-1 (PRP-1) (n = 8), and propranolol dose-2 (PRP-2) (n = 8) groups. In the control group, the rats received no further treatment during the eight-week experimental period after the surgery. The rats in the PRP-1 and PRP-2 groups were given 5 mg/kg and 10 mg/kg propranolol, respectively, every three days for the eight-week experimental period after the surgery. At the end of the experimental period, the rats were euthanized. Blood serum was collected for biochemical analysis, and the implants and surrounding bone tissues were used for the histological analysis. Results: There were no significant differences in the histological analysis results and the biochemical parameters (alkaline phosphatase, calcium, creatinine and phosphorus) of the groups (P > 0.05). Also, in the test groups, there was numerically but not statistically more new bone formation detected compared with the controls. Conclusions: Within the limitations of this study, propranolol did not affect the new bone formation in peri-implant defects.en_US
dc.identifier.doi10.5037/jomr.2021.12302
dc.identifier.issn2029-283X
dc.identifier.issue3en_US
dc.identifier.pmid34777724
dc.identifier.urihttps://doi.org/10.5037/jomr.2021.12302
dc.identifier.urihttps://hdl.handle.net/11468/19851
dc.identifier.volume12en_US
dc.identifier.wosWOS:001077307700002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherUab Stilus Optimusen_US
dc.relation.ispartofJomr-Journal of Oral & Maxillofacial Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBoneen_US
dc.subjectPeri-Implantitisen_US
dc.subjectPropranololen_US
dc.subjectRegenerationen_US
dc.titleEffects of Systemic Propranolol Application on the New Bone Formation in Periimplant Guided Bone Regenerationen_US
dc.titleEffects of Systemic Propranolol Application on the New Bone Formation in Periimplant Guided Bone Regeneration
dc.typeArticleen_US

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