Influence of patient training on persistence, compliance, and tolerability of different dosing frequency regimens of bisphosphonate therapy: An observational study in Turkish patients with postmenopausal osteoporosis

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dc.contributor.authorAkarırmak, Ülkü
dc.contributor.authorKoçyiğit, Hikmet
dc.contributor.authorEskiyurt, Nurten
dc.contributor.authorEsmaeilzadeh, Sina
dc.contributor.authorKuru, Ömer
dc.contributor.authorYalçınkaya, Ebru Yılmaz
dc.contributor.authorPeker, Özlen
dc.contributor.authorÇevik, Remzi
dc.date.accessioned2024-04-24T17:56:46Z
dc.date.available2024-04-24T17:56:46Z
dc.date.issued2016
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fiziksel Tıp ve Rehabilitasyon Ana Bilim Dalıen_US
dc.description.abstractObjective: In our study, we aimed to evaluate the influence of training on compliance and persistence with bisphosphonate treatment given on a weekly vs. monthly basis in postmenopausal osteoporosis patients. Methods: A total of 979 patients with postmenopausal osteoporosis (mean age: 63.2 ± 7.2 years) were included in this national, multicenter, prospective non-interventional observational cohort registry study. Patients were randomized into training (n = 492, 50.3%, mean age: 63.4 ± 7.2 years) and control (n = 487, 49.7%, mean age: 63.0 ± 7.1 years) groups. Patients in each intervention group were given weekly (44.9% and 44.6% for training and control subjects, respectively) or monthly (55.1% and 55.4%, respectively) bisphosphonate regimens. After the initial visit, patients were followed up at three-month intervals throughout 12 months of treatment for evaluation of persistence, compliance and adverse events. Results: On average, 79.4% of the patients were persistent with the treatment with a mean of 350.4 days of duration during the 12-month follow-up period. The mean compliance in the compliant and fully compliant group remained at an average of 86.6%. No significant difference was detected between the training and control groups in terms of compliance and persistence. Significantly longer persistence (360.0 ± 89.0 vs. 345.0 ± 108.0 days; p = 0.035), higher percentage of persistent patients (83.4% vs. 74.2%; p = 0.012) and higher compliance rates (88.8% vs. 83.3%; p = 0.002) were noted in monthly regimen patients in comparison to those given weekly regimen.en_US
dc.identifier.citationAkarırmak, Ü., Koçyiğit, H., Eskiyurt, N., Esmaeilzadeh, S., Kuru, Ö., Yalçınkaya, E. Y. ve diğerleri. (2016). Influence of patient training on persistence, compliance, and tolerability of different dosing frequency regimens of bisphosphonate therapy: An observational study in Turkish patients with postmenopausal osteoporosis. Acta Orthopaedica et Traumatologica Turcica, 50(4), 592-599.
dc.identifier.doi10.1590/S0080-623420160000500008
dc.identifier.endpage599en_US
dc.identifier.issn1017-995X
dc.identifier.issue4en_US
dc.identifier.pmid27524671
dc.identifier.scopus2-s2.0-84994106436
dc.identifier.scopusqualityQ2
dc.identifier.startpage592en_US
dc.identifier.urihttps://doi.org/10.1590/S0080-623420160000500008
dc.identifier.urihttps://hdl.handle.net/11468/23658
dc.identifier.volume50en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Association of Orthopaedics and Traumatologyen_US
dc.relation.ispartofActa Orthopaedica et Traumatologica Turcica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBisphosphonateen_US
dc.subjectComplianceen_US
dc.subjectDosing regimenen_US
dc.subjectOsteoporosisen_US
dc.subjectPersistenceen_US
dc.subjectTrainingen_US
dc.titleInfluence of patient training on persistence, compliance, and tolerability of different dosing frequency regimens of bisphosphonate therapy: An observational study in Turkish patients with postmenopausal osteoporosisen_US
dc.titleInfluence of patient training on persistence, compliance, and tolerability of different dosing frequency regimens of bisphosphonate therapy: An observational study in Turkish patients with postmenopausal osteoporosis
dc.typeArticleen_US

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