Pankreas kanseri tanılı hastalarımızda prognostik faktörlerin incelenmesi
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Dicle Üniversitesi Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Pankreas kanseri oldukça kötü prognozlu bir hastalık olup, insidansı giderek artmaktadır. Bu hastalıkta birden
fazla prognostik belirteç bulunmaktadır. Bu çalışmadaki amaç kliniğimizde pankreas kanseri tanısı alan hastaların yaşam
süresini etkileyen prognostik faktörleri saptamaktı.
Yöntemler: Kliniğimize Ocak 2011-Haziran 2020 tarihleri arasında başvuran ve pankreas kanseri tanısı konulan 127
hastanın demografik ve klinik özellikleri, laboratuvar sonuçları, kontrastlı abdomen tomografisi bulguları ve tedavilere
cevapları retrospektif olarak değerlendirildi.
Bulgular: Hastaların 85’i (%67) erkek 42’si (%33) kadın olup, yaş ortalaması 62,6±12,5 (27-90) yıl, ortalama sağ kalma
süresi 11,6±1,3 ay; 1 yıllık ortalama sağ kalım oranı %31 ve 5 yıllık ortalama sağ kalım oranı %0,9 idi. Pankreas kanseri
prognozu ile cinsiyet, tümör çapı, tümör lokalizasyonu, DM varlığı, patolojik LAP varlığı, vasküler invazyon, kemoterapi
alınması, serum CA 19-9 ve CA125 seviyesi arasında anlamlı ilişki saptanmazken, ileri yaş (p=0.01), karaciğer metastazı
(P=0.016) ve yüksek serum CEA düzeyinin (p=0.013) kötü prognostik faktör ve cerrahi rezeksiyon yapılmasının
(p=0.039) iyi prognostik faktör olduğu saptandı.
Sonuç: Pankreas kanseri tedavisi sırasında hastalığın prognozunu etkileyen faktörlerin göz önünde bulundurulması
faydalı olabilir.
Objective: Pancreatic cancer is a disease with very poor prognosis and its incidence is gradually increasing. There are more than one prognostic marker in this disease. The aim of this study was to determine the prognostic factors affecting the survival of patients diagnosed with pancreatic cancer in our clinic. Methods: The demographic and clinical characteristics, laboratory results, contrast-enhanced abdominal tomography findings and responses to treatments of 127 patients who were admitted to our clinic between January 2011 and June 2020 and were diagnosed with pancreatic cancer were retrospectively evaluated. Results: 85 (67%) of the patients were male and 42 (33%) were female, the mean age was 62.6 ± 12.5 (27-90) years, the mean survival time was 11.6 ± 1.3 months; The 1-year mean survival rate was 31% and the 5-year mean survival rate was 0.9%. There was no significant relationship between pancreatic cancer prognosis and gender, tumor size, tumor location, presence of DM, presence of pathological LAP, vascular invasion, chemotherapy, serum CA 19-9 and CA125 levels. Advanced age (p = 0.01), liver metastasis (P = 0.016) and high serum CEA level (p = 0.013) were found to be poor prognostic factors, and surgical resection (p = 0.039) was found to be a good prognostic factor. Conclusion: It may be beneficial to consider the factors affecting the prognosis of the disease during the treatment of pancreatic cancer.
Objective: Pancreatic cancer is a disease with very poor prognosis and its incidence is gradually increasing. There are more than one prognostic marker in this disease. The aim of this study was to determine the prognostic factors affecting the survival of patients diagnosed with pancreatic cancer in our clinic. Methods: The demographic and clinical characteristics, laboratory results, contrast-enhanced abdominal tomography findings and responses to treatments of 127 patients who were admitted to our clinic between January 2011 and June 2020 and were diagnosed with pancreatic cancer were retrospectively evaluated. Results: 85 (67%) of the patients were male and 42 (33%) were female, the mean age was 62.6 ± 12.5 (27-90) years, the mean survival time was 11.6 ± 1.3 months; The 1-year mean survival rate was 31% and the 5-year mean survival rate was 0.9%. There was no significant relationship between pancreatic cancer prognosis and gender, tumor size, tumor location, presence of DM, presence of pathological LAP, vascular invasion, chemotherapy, serum CA 19-9 and CA125 levels. Advanced age (p = 0.01), liver metastasis (P = 0.016) and high serum CEA level (p = 0.013) were found to be poor prognostic factors, and surgical resection (p = 0.039) was found to be a good prognostic factor. Conclusion: It may be beneficial to consider the factors affecting the prognosis of the disease during the treatment of pancreatic cancer.
Açıklama
Anahtar Kelimeler
Pankreas kanseri, Tümör markırları, Prognostik faktörler, Pancreatic cancer, Tumor markers, Prognostic factors
Kaynak
Dicle Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
49
Sayı
1
Künye
Yolaçan, R., Yiğit, E., Karabulut, Ü., Üzel, A., Uçmak, F. ve Kaya, M. (2022). Pankreas kanseri tanılı hastalarımızda prognostik faktörlerin incelenmesi. Dicle Tıp Dergisi, 49(1), 159-167.
