GENETIC ANALYSIS IN PREGNANCY WITH FETAL PATHOLOGIC ULTRASOUND FINDINGS

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dc.contributor.authorSimsek, Selda
dc.contributor.authorTurkyilmaz, Aysegul
dc.contributor.authorOral, Diclehan
dc.contributor.authorYalinkaya, Ahmet
dc.contributor.authorTekes, Selahaddin
dc.contributor.authorAkbas, Halit
dc.contributor.authorBudak, Turgay
dc.date.accessioned2024-04-24T17:27:41Z
dc.date.available2024-04-24T17:27:41Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the relationship between fetal abnormal karyotype and fetal abnormal ultrasound examination in pregnancy A total of 191 women were analyzed for karyotyping after detection of a soft marker or of major malformations at the routine antenatal USG, for the period 2007-2011. A total of 191 amniotic fluid samples were analyzed for chromosome aberrations and the fetal karyotype was abnormal in 24.6 % (47/191) of all cases. Among them, 13 cases were with trisomy 21; 5 cases with trisomy 18; 1 case with trisomy 13; 2 cases with triploidy; 7 cases with karyotype of 45,X; 1 case with karyotype 47,XXY; and 18 cases with other abnormal chromosome structures. One hundred and fifty-two karyotyping procedures were done due to the finding of a single sonographic marker Within this group, 17.1 % of the karyotypes were abnormal. Thirty-nine karyotyping procedures were done due to the finding of a multiple sonographic marker In this group, 53.8 % of the karyotypes were abnormal. The overall termination rate was 61.7 % (29/47) in cases with a fetus affected by chromosomal abnormalities. Ultrasound examination is important in prenatal diagnosis. We suggest that karyotype analysis should be advised to pregnant women with an abnormal fetus in the ultrasound examination.en_US
dc.identifier.doi10.5504/BBEQ.2013.0018
dc.identifier.endpage3833en_US
dc.identifier.issn1310-2818
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84883251889
dc.identifier.scopusqualityQ3
dc.identifier.startpage3829en_US
dc.identifier.urihttps://doi.org/10.5504/BBEQ.2013.0018
dc.identifier.urihttps://hdl.handle.net/11468/20144
dc.identifier.volume27en_US
dc.identifier.wosWOS:000320828500014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherDiagnosis Press Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGenetic Analysisen_US
dc.subjectPrenatal Diagnosisen_US
dc.subjectKaryotypingen_US
dc.subjectFetal Anomalyen_US
dc.subjectFetal Usgen_US
dc.titleGENETIC ANALYSIS IN PREGNANCY WITH FETAL PATHOLOGIC ULTRASOUND FINDINGSen_US
dc.titleGENETIC ANALYSIS IN PREGNANCY WITH FETAL PATHOLOGIC ULTRASOUND FINDINGS
dc.typeArticleen_US

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