A COMPARATIVE REVIEW OF PEDIATRIC AND ADULT PATIENTS WITH MILIARY TUBERCULOSIS

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dc.contributor.authorTanrikulu, Cetin
dc.contributor.authorGurkan, Fuat
dc.contributor.authorDagli, Canan Eren
dc.contributor.authorGozu, Ayfer
dc.contributor.authorSuner, Ali
dc.date.accessioned2024-04-24T17:20:24Z
dc.date.available2024-04-24T17:20:24Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: Miliary tuberculosis (MTB) is a serious and rare form of tuberculosis. Studies comparatively reviewed children and adults with MTB are lacking. Methods: We retrospectively evaluated 56 pediatric and 26 adult MTB patients at a university hospital, between 1990 and 2003 Results: The median age at presentation was 3.5 years for children and 38 years for adults. Thirtyeight of all patients of whom 86.8% were children had family history of tuberculosis Presenting symptoms and signs of adult and pediatric patients were loss of weight (51.8% vs. 61.5%), anorexia (76.9% vs. 57.8%), dyspnea (12.5% vs. 57.8%), diarrhea/ vomiting (35.0% vs. 27.0%), fever (53.8% vs. 17.9%), hepatomegaly (30.8% vs. 51.8%), pulmonary crepitations (42.3% vs. 42.9) and cough (46.2% vs. 35.7%), respectively. The presenting symptoms/signs and laboratory abnormalities were generally more frequent in adults. Detected laboratory abnormalities were leukocytosis (73.2%), increased sedimentation rate ( 73.2%), anemia (52.4%), hypoalbuminemia (47.6%), elevated liver transaminases (36.6%), elevated lactate dehydrogenase (50.0%) and hyponatremia (25.6%) in whole study group. The diagnosis was proven microbiologically in 15 (18.3%) patients. Among 56 pediatric cases, there were 8 (14.3%) children with positive BCG scar and only 16 (28.6%) children with positive reaction to 5TU tuberculin test. Radiological findings of all patients, either on chest X-ray or high resolution computerized tomography, were characteristic for MTB. One fourth of patients had accompanying tuberculous meningitis. Predisposing factors for TB were found in 13 patients (15.9%). No patients had HIV infection. Overall 6 (7.3%) patients had died. Conclusion: High rate of history of family contact and low rate of BCG vaccination in our patients with MTB were significant public health problems. Identifying different features in children and adults may contribute to early diagnosis of MTB, which is highly relevant to its outcome.en_US
dc.identifier.doi10.29333/ejgm/82488
dc.identifier.endpage72en_US
dc.identifier.issn1304-3889
dc.identifier.issn1304-3897
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-41449103925
dc.identifier.scopusqualityN/A
dc.identifier.startpage67en_US
dc.identifier.urihttps://doi.org/10.29333/ejgm/82488
dc.identifier.urihttps://hdl.handle.net/11468/19015
dc.identifier.volume4en_US
dc.identifier.wosWOS:000421880700003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherModestum Ltden_US
dc.relation.ispartofEuropean Journal of General Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMiliary Tuberculosisen_US
dc.subjectDiagnosisen_US
dc.subjectClinical Characteristicsen_US
dc.subjectAdulten_US
dc.subjectChilden_US
dc.titleA COMPARATIVE REVIEW OF PEDIATRIC AND ADULT PATIENTS WITH MILIARY TUBERCULOSISen_US
dc.titleA COMPARATIVE REVIEW OF PEDIATRIC AND ADULT PATIENTS WITH MILIARY TUBERCULOSIS
dc.typeArticleen_US

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