Can long-term exposure to chromium improve insulin sensitivity in chromium mine workers?

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dc.contributor.authorTuzcu, Alpaslan
dc.contributor.authorBahçeci, Mithat
dc.contributor.authorDursun, Mehmet Emin
dc.contributor.authorParmaksız, Y.
dc.contributor.authorErtem, Melikşah
dc.contributor.authorDalgıç, A.
dc.contributor.authorTurgut, Cengiz
dc.contributor.authorKale, Ebru
dc.date.accessioned2024-04-24T15:59:28Z
dc.date.available2024-04-24T15:59:28Z
dc.date.issued2004
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractThe purpose of this work was to evaluate insulin sensitivity in chromium mine workers exposed to chromium chronically. Body mass index, waist circumference, fat mass and percent, lipid levels, serum glucose, insulin, leptin and chromium levels, HOMA (%S), and HOMA (%B) values were measured in 93 male workers and 94 age- and body mass index-matched healthy controls. Fat mass and fat percent of workers were higher than control subjects (P < 0;01 and P < 0.0001, respectively). Mean insulin level of the workers was lower than control subjects (6.2 +/- 4.9 muU/mL and 9.38 +/- 5, respectively, P < 0.0001). Mean serum leptin levels was also lower than the control group (8.47 +/- 6.5 ng/mL and 19.0 +/- 10.8, respectively, P < 0.0001). Serum chromium was higher than the control subjects (407.7 +/- 224.2 nmol/L and 4.45 +/- 3.9, respectively, P < 0.00001). Mean HOMA (%S) index of workers was higher than control subjects (114.4 +/- 55.6 and 55.7 +/- 40.6, P < 0.001). Serum high-density lipoprotein cholesterol levels of the workers were significantly higher than the control group (P < 0.02). In conclusion, long-term exposure to chromium may improve insulin sensitivity and beta-cell function. This improvement appears to be a result of low body fat mass and fat percent in body composition. In addition chromium usage may have useful effects in the insulin sensitivity and therefore in development of type 2 diabetes mellitus.en_US
dc.identifier.citationTuzcu, A., Bahçeci, M., Dursun, M. E., Parmaksız, Y., Ertem, M., Dalgıç, A. ve diğerleri. (2004). Can long-term exposure to chromium improve insulin sensitivity in chromium mine workers?. Journal of Trace Elements in Experimental Medicine, 17(1), 55-63.
dc.identifier.doi10.1002/jtra.10053
dc.identifier.endpage63en_US
dc.identifier.issn0896-548X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-1642580876
dc.identifier.scopusqualityN/A
dc.identifier.startpage55en_US
dc.identifier.urihttps://doi.org/10.1002/jtra.10053
dc.identifier.urihttps://hdl.handle.net/11468/14082
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/jtra.10053
dc.identifier.volume17en_US
dc.identifier.wosWOS:000188546700006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTuzcu, Alpaslan
dc.institutionauthorBahçeci, Mithat
dc.institutionauthorDursun, Mehmet Emin
dc.institutionauthorParmaksız, Y.
dc.institutionauthorErtem, Melikşah
dc.institutionauthorDalgıç, A.
dc.institutionauthorTurgut, Cengiz
dc.institutionauthorKale, Ebru
dc.language.isoenen_US
dc.publisherWiley-Lissen_US
dc.relation.ispartofJournal of Trace Elements in Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHoma (%S)en_US
dc.subjectHoma (%B)en_US
dc.subjectInsulin Levelen_US
dc.subjectObesityen_US
dc.titleCan long-term exposure to chromium improve insulin sensitivity in chromium mine workers?en_US
dc.titleCan long-term exposure to chromium improve insulin sensitivity in chromium mine workers?
dc.typeArticleen_US

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