Effects of timing in the applications of radiotherapy after transverse rectus abdominis musculocutaneous flap in rats

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dc.contributor.authorBinicier, O.
dc.contributor.authorCaskan, P. K.
dc.contributor.authorKapi, E.
dc.contributor.authorBozkurt, M.
dc.contributor.authorZincircioglu, S. B.
dc.contributor.authorKulahci, Y.
dc.contributor.authorSelcuk, C. T.
dc.date.accessioned2024-04-24T17:27:33Z
dc.date.available2024-04-24T17:27:33Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The present study aimed to investigate flap status in relation to the timing of radiotherapy (RT) in an experimental rat model of irradiated transverse rectus abdominis musculocutaneous (TRAM) flap. Materials and Methods: Fifty-six adult male Sprague-Dawley experiments were separated in seven groups in terms of flap surgery and RT. The groups comprised sham group, control (Ctrl) group, RT group, and RT plus surgery (RT+Surg) group, which was further separated in four groups depending on the timing of postoperative RT as RT+Surg-10 (RT on postoperative 10th day), RT+Surg-20 (RT on postoperative 20th day), RT+Surg-30 (RT on postoperative 30th day), and RT+Surg-40 (RT on postoperative 40th day). All the rats were sacrificed 8 weeks after the RT administration for histopathological analysis. Results: Compared with the RT+Surg-10 and RT+Surg-20 groups, the hyalinization and collagenization scores in RT+Surg-30 were determined to be significantly lower. Fibrosis scores were lower in the RT+Surg-30 group compared with the RT+Surg-20 group, whereas significantly lower inflammation scores were determined in the RT + Surg-40 group and significantly higher dermal thickness in the RT+Surg-30 group compared with the RT+Surg-10 group. Conclusions: The findings from this model of irradiated flap revealed the significance of the time lag among flap application and postoperative RT for histopathological outcome, emphasized the potential role of at least a 30- to 40day interval between surgery and RT in achieving more favorable flap status.en_US
dc.identifier.doi10.52547/ijrr.20.3.19
dc.identifier.endpage655en_US
dc.identifier.issn2322-3243
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85141208443
dc.identifier.scopusqualityQ4
dc.identifier.startpage649en_US
dc.identifier.urihttps://doi.org/10.52547/ijrr.20.3.19
dc.identifier.urihttps://hdl.handle.net/11468/20047
dc.identifier.volume20en_US
dc.identifier.wosWOS:000862878800019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherIjrr-Iranian Journal Radiation Resen_US
dc.relation.ispartofInternational Journal of Radiation Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTram Flapen_US
dc.subjectRaten_US
dc.subjectTiming Of Irradiationen_US
dc.subjectExperimentalen_US
dc.subjectHistopathologi-Cal Outcomesen_US
dc.titleEffects of timing in the applications of radiotherapy after transverse rectus abdominis musculocutaneous flap in ratsen_US
dc.titleEffects of timing in the applications of radiotherapy after transverse rectus abdominis musculocutaneous flap in rats
dc.typeArticleen_US

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