In vitro DNA damage, protein oxidation protective activity and antioxidant potentials of almond fruit (Amygdalus trichamygdalus) parts (hull and drupe) using soxhlet ethanol extraction

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dc.contributor.authorMeydan, Ismet
dc.contributor.authorKizil, Goksel
dc.contributor.authorDemir, Halit
dc.contributor.authorCeken Toptanci, Bircan
dc.contributor.authorKizil, Murat
dc.date.accessioned2024-04-24T16:10:37Z
dc.date.available2024-04-24T16:10:37Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractAlmond is a nut that is consumed abundantly all over the world. In Turkey, almonds are grown in most parts of the Turkey and the consumption of nuts has become an essential part of healthy life. Almond contain powerful nutrients, which may be related to their fatty acid composition. Therefore, the aim of present study was to investigate the antioxidant potentials and the protective activity of ethanol extraction ofAmygdalus trichamygdalusfruit parts (Hull and Drupe) against the lipid peroxidation, oxidative DNA damage and protein oxidation using soxhlet ethanol extraction. To the best of our knowledge, our study can be evaluated as the first report. The total phenolic content was found to be equivalent to 28.16 +/- 9.990 mu g/g gallic acid extract and the total flavonoid content was equivalent to 8.866 +/- 0.208 mu g/g quercetin extract. The present study shows thatA. trichamygdalusextract have good protective activity against lipid peroxidation in the FeCl2-H(2)O(2)system. The extract also showed a strong DPPH radical scavenging ability in a concentration-dependent manner. At 2000 mu g/ml, the DPPH radical scavenging activity was found to be 84.47 +/- 0.147%. The protein oxidation was also inhibited byA. trichamygdalusextract. At 2000 mu g/ml,A. trichamygdalusextract protected protein oxidation by 76.27 +/- 1.14%. In addition, the DNA oxidation damage against OH radicals resulting from H(2)O(2)photolysis was inhibited concentration dependently and DNA damage was suppressed by 50.26 +/- 2.6% at 1000 mu g/ml concentration. The results suggest thatA. trichamygdalusfruit extract have antioxidant activity and protect lipid, protein and DNA against oxidative damage. Therefore, the extract may be useful in the food industry as natural antioxidants.en_US
dc.description.sponsorshipVAN YYU Scientific Research Projects Project [FDK-2017-5305]; Presidency of the Scientific Research Projectsen_US
dc.description.sponsorshipThis study was supported by VAN YYU Scientific Research Projects Project as FDK-2017-5305 project. We would like to thank the Presidency of the Scientific Research Projects for their support.en_US
dc.identifier.doi10.1007/s13596-020-00491-1
dc.identifier.endpage579en_US
dc.identifier.issn2662-4052
dc.identifier.issn2662-4060
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85089779435
dc.identifier.scopusqualityQ2
dc.identifier.startpage571en_US
dc.identifier.urihttps://doi.org/10.1007/s13596-020-00491-1
dc.identifier.urihttps://hdl.handle.net/11468/14972
dc.identifier.volume20en_US
dc.identifier.wosWOS:000564878700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAdvances in Traditional Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectA. Trichamygdalusen_US
dc.subjectAlmonden_US
dc.subjectLipid Oxidationen_US
dc.subjectProtein Oxidationen_US
dc.subjectDna Damageen_US
dc.titleIn vitro DNA damage, protein oxidation protective activity and antioxidant potentials of almond fruit (Amygdalus trichamygdalus) parts (hull and drupe) using soxhlet ethanol extractionen_US
dc.titleIn vitro DNA damage, protein oxidation protective activity and antioxidant potentials of almond fruit (Amygdalus trichamygdalus) parts (hull and drupe) using soxhlet ethanol extraction
dc.typeArticleen_US

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