Evaluation of children and adolescent with cystic fibrosis by pancreatic elastography

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dc.contributor.authorYilmaz, Kamil
dc.contributor.authorHattapoglu, Salih
dc.contributor.authorSen, Velat
dc.contributor.authorKarabel, Musemma
dc.contributor.authorKan, Ahmet
dc.contributor.authorYilmaz, Engin Deniz
dc.contributor.authorSen, Hadice Selimoglu
dc.date.accessioned2024-04-24T17:11:49Z
dc.date.available2024-04-24T17:11:49Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground Cystic fibrosis (CF) is an autosomal recessively inherited disease. Clinical findings vary by age of the patient, the organ systems involved, and the severity of the CFTR gene mutation. Pancreatic and liver involvement is prominent and exocrine pancreatic insufficiency is observed in the majority of patients. Point shear wave elastography (pSWE) is a non-invasive method that can quantitatively determine tissue elasticity and stiffness. In this study, the morphological evaluation of the pancreas was performed using the pSWE technique in pediatric patients diagnosed with CF. The effectiveness of this method for the early detection of pancreatic insufficiency was investigated. Methods Fifty-five patients with CF (24 girls, 31 boys) and 60 healthy children (29 girls, 31 boys) without any chronic diseases and who were suitable for the pSWE examination were included in the study. Results The mean value of pSWE was 1.12 +/- 0.16 in the healthy group and 0.97 +/- 0.16 in the patients with cystic fibrosis. There was a statistically significant difference between the two groups (P < 0.001). Significant negative correlations were found between pSWE and age (r = -0.319; P = 0.018), height (r = -0.293; P = 0.03), serum glucose (r = -0.346; P = 0.01), HbA1C (r = -0.592; P = 0.02), and duration of the disease (r = -0.806; P < 0.001). Conclusions Investigating pancreatic elasticity and detecting pancreatic insufficiency using pSWE (a simple, inexpensive, and non-invasive method) in the early period before overt laboratory and clinical symptoms of EPI appear can contribute positively to long-term results in young patients with CF.en_US
dc.identifier.doi10.1111/ped.14951
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue1en_US
dc.identifier.pmid34390069
dc.identifier.urihttps://doi.org/10.1111/ped.14951
dc.identifier.urihttps://hdl.handle.net/11468/17736
dc.identifier.volume64en_US
dc.identifier.wosWOS:000779881300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatrics International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCystic Fibrosisen_US
dc.subjectPancreasen_US
dc.subjectPoint Shear Wave Elastographyen_US
dc.titleEvaluation of children and adolescent with cystic fibrosis by pancreatic elastographyen_US
dc.titleEvaluation of children and adolescent with cystic fibrosis by pancreatic elastography
dc.typeArticleen_US

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