Determination of chemical components of the endemic species Allium turcicum L. plant extract by LC-MS/MS and evaluation of medicinal potentials

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dc.contributor.authorİpek, Polat
dc.contributor.authorAtalar, Mehmet Nuri
dc.contributor.authorBaran, Ayşe
dc.contributor.authorBaran, Mehmet Fırat
dc.contributor.authorOmmati, Mohammad Mehdi
dc.contributor.authorKaradağ, Musa
dc.contributor.authorZor, Murat
dc.date.accessioned2024-04-24T17:56:08Z
dc.date.available2024-04-24T17:56:08Z
dc.date.issued2024
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümüen_US
dc.description.abstractThe Allium turcicum L. (Zuzubak) plant as a cultivated vegetable have various health benefits and consumed as a food. Due to the shortcoming evidence in literature and the importance of this plant in folk medicine, in the present study, for the first time, we evaluated the bioactive profile of components (using LC-MS/MS), cytotoxicity, anticancer, antioxidant, and antibacterial prospectives of Zuzubak methanol extract. Reported results show that the extract is rich in bioactive compounds and has anticancer activity with breast cancer cells (MCF-7), human prostate cancer cells (DU-145), and Human osteosarcoma cancer Cell lines of (IC50) in dose dependent manner in the concentration range of 31.25 ?g/mL and 2000 ?g/mL for 24 and 48 h. Western blotting results determined that the extract significantly suppressed the growth of U2OS, MCF-7, and DU-145 cancer cells by down expression of Ang-1 (angiogenic protein) and Beclin-1 (autophagy protein) and overexpression of Bax (a proapoptotic protein). The oxidative stress indices showed a reduction in RPE-1 and MCF-7 cells and an upsurge in U2OS and DU-145 cells. Additionally, the antimicrobial assay showed suppression of the growth of various pathogenic microorganisms in 4.00–8.00 ?g/concentrations of Zuzubak extract using the microdilution method. The phytochemicals identified showed promising anticancer, antioxidant effects, and antimicrobial properties, representing a valuable herbal source for drug development studies. © 2024 The Authorsen_US
dc.description.sponsorshipResearch Center for Pharmaceutical Nanotechnology, RCPN; 73,733en_US
dc.description.sponsorshipThis work was supported by the Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute of Tabriz University of Medical Sciences, Tabriz, Iran (Grant no: 73,733).en_US
dc.identifier.citationİpek, P., Atalar, M. N., Baran, A., Baran, M., F., Ommati, M. M., Karadağ, M. ve diğerleri. (2024). Determination of chemical components of the endemic species Allium turcicum L. plant extract by LC-MS/MS and evaluation of medicinal potentials. Heliyon, 10(6), 1-12.
dc.identifier.doi10.1016/j.heliyon.2024.e27386
dc.identifier.issn2405-8440
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85188732979
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.heliyon.2024.e27386
dc.identifier.urihttps://hdl.handle.net/11468/23307
dc.identifier.volume10en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofHeliyon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAllium turcicumen_US
dc.subjectAntimicrobial activityen_US
dc.subjectCytotoxic activityen_US
dc.subjectZuzubaken_US
dc.titleDetermination of chemical components of the endemic species Allium turcicum L. plant extract by LC-MS/MS and evaluation of medicinal potentialsen_US
dc.titleDetermination of chemical components of the endemic species Allium turcicum L. plant extract by LC-MS/MS and evaluation of medicinal potentials
dc.typeArticleen_US

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