THE EFFECTS OF ERYTHROPOIETIN ON BACTERIAL TRANSLOCATION AND INFLAMMATORY RESPONSE IN AN EXPERIMENTAL INTESTINAL OBSTRUCTION MODEL IN RATS

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dc.contributor.authorKapan, Murat
dc.contributor.authorOnder, Akin
dc.contributor.authorYuksel, Hatice
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorFirat, Ugur
dc.contributor.authorTekin, Recep
dc.contributor.authorGul, Mesut
dc.date.accessioned2024-04-24T17:20:20Z
dc.date.available2024-04-24T17:20:20Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Intestinal obstruction results in distortion of balance of antiinflammatory cytokines and release of oxidants, and also leads to bacterial translocation, sepsis and multiple organ failure. Asymmetric dimethylarginine is related to multiple organ failure as a new prognostic marker. Erythropoietin reduces the inflammatory response by decreasing the levels of proinflammatory cytokines and cytokine-induced apoptosis. In this study, we aimed to investigate the effectiveness of erythropoietin in reducing the severity of bacterial translocation and inflammatory response after intestinal obstruction and the relation between asymmetric dimethylarginine and inflammatory markers. Methods: Forty Wistar albino rats (200-250 g) were divided into 4 groups as follows: Group 1 (Sham), only ileocaecal junction dissection; Group 2 (Erythropoietin), ileocaecal junction dissection and 3000 IU/kg erythropoietin subcutaneously; Group 3 (Intestinal Obstruction), complete ileal ligation; Group 4 (Intestinal Obstruction + Erythropoietin), complete ileal ligation and 3000 IU/kg erythropoietin subcutaneously. After 24 hours, the rats were sacrificed by taking blood from the heart for biochemical analyses. Peritoneal swab culture, liver, mesenteric lymph nodes, spleen and ileum were collected for microbiological and histopathological examinations. Results: Erythropoietin reduced the secretion of inflammatory cytokines, oxidative damage and bacterial translocation, prevented the formation of inflammatory changes in the intestine, liver, spleen and mesenteric lymph nodes, and also significantly prevented the formation of intestinal damage after intestinal obstruction (p<0.05). Conclusions: Asymmetric dimethylarginine levels did not differ between the groups. Erythropoietin may be useful to preserve from intestinal injury and related sepsis in patients with intestinal obstruction. Asymmetric dimethylarginine is not a suitable prognostic marker.en_US
dc.description.sponsorshipDicle Universityen_US
dc.description.sponsorshipThis study was supported by Dicle University, Coordination of Scientific Research Projects.en_US
dc.identifier.doi10.2478/v10011-012-0001-6
dc.identifier.endpage46en_US
dc.identifier.issn1452-8258
dc.identifier.issn1452-8266
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84872619242
dc.identifier.scopusqualityQ3
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org/10.2478/v10011-012-0001-6
dc.identifier.urihttps://hdl.handle.net/11468/18957
dc.identifier.volume32en_US
dc.identifier.wosWOS:000312464800007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSoc Medical Biochemists Serbiaen_US
dc.relation.ispartofJournal of Medical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectErythropoietinen_US
dc.subjectIntestinal Obstructionen_US
dc.subjectBacterial Translocationen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.titleTHE EFFECTS OF ERYTHROPOIETIN ON BACTERIAL TRANSLOCATION AND INFLAMMATORY RESPONSE IN AN EXPERIMENTAL INTESTINAL OBSTRUCTION MODEL IN RATSen_US
dc.titleTHE EFFECTS OF ERYTHROPOIETIN ON BACTERIAL TRANSLOCATION AND INFLAMMATORY RESPONSE IN AN EXPERIMENTAL INTESTINAL OBSTRUCTION MODEL IN RATS
dc.typeArticleen_US

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