Synthesis, characterization, UV-Vis absorption and cholinesterase inhibition properties of bis-indolyl imine ligand systems

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dc.contributor.authorSaglam, Mehmet F.
dc.contributor.authorBingul, Murat
dc.contributor.authorSenkuytu, Elif
dc.contributor.authorBoga, Mehmet
dc.contributor.authorZorlu, Yunus
dc.contributor.authorKandemir, Hakan
dc.contributor.authorSengul, Ibrahim F.
dc.date.accessioned2024-04-24T16:15:38Z
dc.date.available2024-04-24T16:15:38Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractA number of bis-indolyl imine helical structures has successfully been synthesized employing Schiff base reaction conditions starting from 4,6-dimethoxy-2,3-diphenylindole with different o-phenyl diamines as pi-spacer bridged. The structures of targeted compounds were identified by FT-IR, mass, H-1 and C-13 NMR spectroscopy along with single crystal X-ray diffraction techniques. The ground state absorption properties of the bis-indolyl compounds were also investigated utilizing UV-Vis absorption spectroscopy. As the biological aspect of the synthesized compounds, the anticholinesterase potency was investigated towards the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. The highest inhibition was determined in the presence of compound 9 with the values of 89.21 and 96.06, better than standard Galantamine, for AChE and BChE, respectively. (C) 2020 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipResearch Found of the Gebze Technical University [2019-A-105-37]en_US
dc.description.sponsorshipThis work has been supported by Research Found of the Gebze Technical University (Project Number: 2019-A-105-37). We thank to Dr. Michael Dieter Worle for his support in refining compound 10.en_US
dc.identifier.doi10.1016/j.molstruc.2020.128308
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85083710608
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2020.128308
dc.identifier.urihttps://hdl.handle.net/11468/15874
dc.identifier.volume1215en_US
dc.identifier.wosWOS:000537220200005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIndoleen_US
dc.subjectSchiff Baseen_US
dc.subjectUv-Visen_US
dc.subjectCholinesterase Inhibitoren_US
dc.titleSynthesis, characterization, UV-Vis absorption and cholinesterase inhibition properties of bis-indolyl imine ligand systemsen_US
dc.titleSynthesis, characterization, UV-Vis absorption and cholinesterase inhibition properties of bis-indolyl imine ligand systems
dc.typeArticleen_US

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