Evaluation of the effectiveness of remineralization preparations used in paediatric dentistry practices

Aim: The goal of this particular research was to scrutinize theremineralization effects of fluoride varnish, casein phosphopeptideamorphous calcium phosphates (CPP-ACP) and casein phosphopeptideamorphous calcium fluoride phosphates (CPP-ACFP) cream, andtricalcium phosphate (TCP) varnish.Methodology: The study was designed as an experimental researchwhereby samples with early artificial caries lesions were randomlydivided into the following 5 groups with 20 samples in each group: (I)control, (II) fluoride varnish, (III) CPP-ACP cream, (IV) CPP-ACFP creamand (V) TCP varnish. The effectiveness of these remineralization agentswas evaluated using a laser fluorescence device (DIAGNOdent), a scanningelectron microscope (SEM) and energy dispersive X-ray analysis (EDX).Results: In the pre- and post-treatment evaluations, the DIAGNOdentremineralization measurements were statistically significant in all thegroups, except the control group (p < 0.05). In comparison with theDIAGNOdent measurements, the CPP-ACFP group was found to havesignificantly higher remineralization than the fluoride group (p < 0.05),while no significant differences were found between the other groups (p> 0.05). The EDX analysis evaluated the Ca/P ratio between the groups.These results indicated that the CPP-ACFP group was significantly higherthan the control group, the CPP-ACP group and the TCP group (p < 0.05);no significant differences were found between the CPP-ACFP group andthe fluoride group (p > 0.05). In SEM imaging, the most extensive mineralaccumulation was observed in the CPP-ACFP group.Conclusions: Three analytical methods demonstrated that CPP-ACFPwas the most effective remineralization material tested in this study.