A comparative study of a gonadotropin-releasing hormone agonist and finasteride on idiopathic hirsutism

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dc.contributor.authorBayhan G.
dc.contributor.authorBahçeci M.
dc.contributor.authorDemirkol T.
dc.contributor.authorErtem M.
dc.contributor.authorYalinkaya A.
dc.contributor.authorErden A.C.
dc.date.accessioned2024-04-24T18:43:59Z
dc.date.available2024-04-24T18:43:59Z
dc.date.issued2000
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To compare the efficacy of finasteride and GnRH agonist in the treatment of idiopathic hirsutism. Methods: Sixty women with hirsutism were randomly assigned to receive either 5 mg of finasteride or long-acting GnRH agonist (depot leuprolide 3.75 mg) intramuscularly monthly for six months. Main outcome measures: Hirsutism scores were measured according to the Ferriman-Gallway scoring system, and side-effects were monitored for six months of treatment. Blood samples were taken at each visit for assessment of endocrine (FSH, LH, estradiol, progesterone, total and free testosterone, androstenedione, DHEAS-S, 17-OH-P, SHBG), biochemical, and hematologic parameters. Results: All of the patients treated with finasteride or GnRH agonist showed neither menstrual abnormalities nor side-effects. The mean percent change (±SD) in hirsutism scores in the GnRH and finasteride groups was 36%±14% and 14%±11% at six months, respectively. Serum total testosterone, free testosterone, androstenedion and DHEA-S showed a meaningful decrease in patients treated with GnRH agonist. On the other hand, only serum total testosterone and free testosterone levels decreased with finasteride treatment (p<0.05 and p<0.0001, respectively).en_US
dc.identifier.endpage206en_US
dc.identifier.issn0390-6663
dc.identifier.issue3-4en_US
dc.identifier.pmid11214952
dc.identifier.scopus2-s2.0-0034477080
dc.identifier.scopusqualityQ4
dc.identifier.startpage203en_US
dc.identifier.urihttps://hdl.handle.net/11468/24498
dc.identifier.volume27en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofClinical and Experimental Obstetrics and Gynecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAndrogensen_US
dc.subjectEstrogen Replacementen_US
dc.subjectFinasterideen_US
dc.subjectGnrh Agonisten_US
dc.subjectIdiopathic Hirsutismen_US
dc.subjectLeuprolide Acetateen_US
dc.titleA comparative study of a gonadotropin-releasing hormone agonist and finasteride on idiopathic hirsutismen_US
dc.titleA comparative study of a gonadotropin-releasing hormone agonist and finasteride on idiopathic hirsutism
dc.typeArticleen_US

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