Investigation of the protective effect of boric acid against hepatotoxic and nephrotoxic injury induced by acrylamide in rats

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dc.authorid0000-0002-5799-3985en_US
dc.authorid0000-0002-0783-1419en_US
dc.authorid0000-0002-1659-1189en_US
dc.contributor.authorGündüz, Ercan
dc.contributor.authorYıldızhan, Eda
dc.contributor.authorYaman, Mahmut
dc.contributor.authorŞen, Abdullah
dc.contributor.authorAkkuş, Murat
dc.date.accessioned2023-10-16T11:06:14Z
dc.date.available2023-10-16T11:06:14Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Ana Bilim Dalıen_US
dc.description.abstractTo investigate if the administration of boric acid (BA) would exert any protective effect against possible nephrotoxicity and hepatotoxicity induced by the exposure to acrylamide (ACR) in rats. In our study, we used a total of 28 rats that were divided into four equal groups. Group 1: the control group which was not treated with any procedure. Group 2: the ACR group that was administered ACR 50 mg/kg/day via intraperitoneal (i.p) route for 14 days. Group 3: the BA group that was administered BA 200 mg/kg/ day via gavage via peroral (p.o) route for 14 days. Group 4: the ACR+BA group that was administered BA simultaneously with ACR. Total antioxidant and oxidant (TAS/TOS) capacities were measured in all groups at the end of the experiment. In addition, the specimens obtained were evaluated with histopathological examination. Studies showed that the ACR and ACr+BA groups were not significantly different in terms of hepatic TAS level while the TOS level was higher in the ACR group than the ACR+BA group. The groups did not show any significant difference regarding renal TAS and TOS levels. In the histopathological examination of the hepatic tissue, the histopathological injury score of the ACR group was significantly higher than those of the other groups whereas it was significantly lower in the ACR+BA group than the ACR group. Our study concluded that Boric acid had a protective effect against acrylamide-induced hepatotoxicity, but not against nephrotoxicity.en_US
dc.identifier.citationGündüz, E., Yıldızhan, E., Yaman, M., Şen, A. ve Akkuş, M. (2023). Investigation of the protective effect of boric acid against hepatotoxic and nephrotoxic injury induced by acrylamide in rats. International Journal of Morphology, 41(2), 368-373.en_US
dc.identifier.doi10.4067/S0717-95022023000200368en_US
dc.identifier.endpage373en_US
dc.identifier.issn0717-9367
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85161413666en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage368en_US
dc.identifier.urihttps://www.scielo.cl/pdf/ijmorphol/v41n2/0717-9502-ijmorphol-41-02-368.pdf
dc.identifier.urihttps://hdl.handle.net/11468/12818
dc.identifier.volume41en_US
dc.identifier.wosWOS:001001066200006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorGündüz, Ercan
dc.institutionauthorYıldızhan, Eda
dc.institutionauthorYaman, Mahmut
dc.institutionauthorŞen, Abdullah
dc.institutionauthorAkkuş, Murat
dc.language.isoenen_US
dc.publisherUniversidad de la Fronteraen_US
dc.relation.ispartofInternational Journal of Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcrylamideen_US
dc.subjectBoric aciden_US
dc.subjectHepatotoxicityen_US
dc.subjectNephrotoxicityen_US
dc.titleInvestigation of the protective effect of boric acid against hepatotoxic and nephrotoxic injury induced by acrylamide in ratsen_US
dc.title.alternativeInvestigación del efecto protector del Ácido bórico contra lesiones hepatotóxicas y nefrotóxicas inducidas por acrilamida en ratasen_US
dc.typeArticleen_US

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