Curcumin reduced diabetic nephropathy in a rat model

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dc.contributor.authorArican, C. D.
dc.contributor.authorGokdemir, G. S.
dc.contributor.authorGokdemir, M. T.
dc.contributor.authorYokus, B.
dc.contributor.authorTasdemir, E.
dc.contributor.authorSermet, A.
dc.date.accessioned2024-04-24T17:24:22Z
dc.date.available2024-04-24T17:24:22Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study aimed to examine the effects of curcumin, a phytochemical antioxidant, on the treatment and care of diabetic nephropathy and to contribute to alternative treatment strategies for diabetes. Male Wistar albino rats (8-10 weeks old) were divided into five groups of seven. Experimental diabetes was induced in all rats except for those in Group 1 (placebo group) by administration of 110 mg/kg nicotinamide, followed by intraperitoneal administration (after 15 min) of 55 mg/kg streptozotocin. Groups 1, 3, 4, and 5 were treated with 0.1 ml normal saline (0.9% NaCl), 150mg/kg/day metformin, 10 mg/kg/day glycazide (diamicron), and 200 mg/kg/day curcumin, respectively. Group 2 did not receive any treatment. Kidney tissues of rats were collected for histopathological examination There were no significant differences in the kidney dimensions of the rats. In the histopathological evaluation of kidney tissues with diabetic nephropathy, glomerular congestion and destruction were observed. Rats treated with curcumin had significantly less kidney damage, based on histopathological analysis, than those treated with the diabetes drugs. We conclude that curcumin has protective effects in kidneys due to its antioxidant properties. It has potential for use, in addition to antidiabetic drugs, for diabetes treatment.en_US
dc.identifier.doi10.4238/gmr19026
dc.identifier.issn1676-5680
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85130382794
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.4238/gmr19026
dc.identifier.urihttps://hdl.handle.net/11468/19633
dc.identifier.volume21en_US
dc.identifier.wosWOS:000836392200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherFunpec-Editoraen_US
dc.relation.ispartofGenetics and Molecular Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidant Effecten_US
dc.subjectCurcuminen_US
dc.subjectDiabetic Nephropathyen_US
dc.subjectPhytochemical Agenten_US
dc.titleCurcumin reduced diabetic nephropathy in a rat modelen_US
dc.titleCurcumin reduced diabetic nephropathy in a rat model
dc.typeArticleen_US

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