Evaluation of Oral Glucose Tolerance Test Results in Children with Cystic Fibrosis

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dc.contributor.authorBestas, Asli
dc.contributor.authorUnal, Edip
dc.contributor.authorKarakaya, Amine Aktar
dc.contributor.authorBeyazit, Nurcan
dc.contributor.authorSavas, Suat
dc.contributor.authorSen, Velat
dc.date.accessioned2025-02-22T14:08:48Z
dc.date.available2025-02-22T14:08:48Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: Current guidelines suggest that patients with cystic fibrosis (CF), who are over the age of 10, should be annually evaluated with oral glucose tolerance test (OGTT). In this study, it was aimed to evaluate the OGTT results in patients above the age of 10, who were followed up in our center with the diagnosis of CF. Methods: In the study, 46 patients with CF at the age of 10 and above, who underwent OGTT were included. Data such as gender, age at diagnosis, anthropometric measurements, lung function (FEV1 %) and the OGTT results were obtained. In the analysis, the patient groups with normal glucose tolerance (NGT) and abnormal glucose tolerance(AGT) were compared. Results: NGT was found in 37(80.4%) of the patients, and AGT was found in 9(19.5%) of the patients. The median fasting glucose levels of the patients in the NGT group and the mean glucose levels measured at 120 minutes in the OGTT were found to be lower compared to the patients in the AGT group(p<0.005). Although the mean body weight, height, VK & Idot;-SDS, FEV1in the AGT group were found to be lower than the patients in the NGT group, the difference was not statistically significant (p>0.05). Conclusion: We detected AGT in approximately 1 out of 5 patients with CF who were at the age of 10 and above. Almost half (44.4%) of the patients with AGT were found to have normal fasting blood glucose levels. Therefore, cystic fibrosis-related diabetes screening should be performed with OGTT instead of fasting blood glucose in patients with CF.en_US
dc.identifier.doi10.14744/SEMB.2024.65983
dc.identifier.endpage394en_US
dc.identifier.issn1302-7123
dc.identifier.issn1308-5123
dc.identifier.issue3en_US
dc.identifier.pmid39411039en_US
dc.identifier.startpage389en_US
dc.identifier.urihttps://doi.org/10.14744/SEMB.2024.65983
dc.identifier.urihttps://hdl.handle.net/11468/29649
dc.identifier.volume58en_US
dc.identifier.wosWOS:001334725300018
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofMedical Bulletin of Sisli Etfal Hospitalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectCystic fibrosisen_US
dc.subjectcystic fibrosis-related diabetesen_US
dc.subjectoral glucose tolerance testen_US
dc.titleEvaluation of Oral Glucose Tolerance Test Results in Children with Cystic Fibrosisen_US
dc.typeArticleen_US

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