ICP-MS Determination of Lead Levels in Autopsy Liver Samples: An Application in Forensic Medicine

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dc.contributor.authorArica, Enes
dc.contributor.authorYuksel, Bayram
dc.contributor.authorYener, Ismail
dc.contributor.authorDolak, Ibrahim
dc.contributor.authorGok, Ertugrul
dc.contributor.authorYilmaz, Eyup
dc.date.accessioned2024-04-24T17:24:46Z
dc.date.available2024-04-24T17:24:46Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe objective of this study was to develop and validate a senstitive ICP-MS method with no gas mode for the determination of Pb levels in autospy liver samples collected from patients in Diyarbakir, Turkey. The microwave-assisted acid digestion procedure was optimized and applied to accurately weighed dry liver samples. The method showed linearity in the range of 0-100 mu g/kg with a detection and quantification limit of 0.72 mu g/kg and 2.18 mu g/kg, respectively. The calibration graph was characterized with excellent correlation coefficients (r=0.9997) for Pb determination. Certified reference material was used to validate the method in terms of accuracy, precision, and recovery. Good agreement was obtained between the certified values and the measured Pb concentrations. Percent recovery and precision for Pb was calculated at 99.5% and 4.29%, respectively. In the autopsy liver samples, the Pb levels ranged from 106.83 mu g/kg to 1932.08 mu g/kg and the mean Pb levels were found at 375.24 +/- 325.46 mu g/kg. As a result of the statistical analysis, the occupation, smoking habit, settlement, gender, and age appeared to have an effect on the Pb levels in the autopsy liver samples. The procedure described is relatively simple, precise, and applicable for routine toxicological Pb determination in human tissue.en_US
dc.description.sponsorshipDicle University Scientific Research Project Coordination Unit (BAP) [14-MYO-82]en_US
dc.description.sponsorshipThis work was financially supported by the Dicle University Scientific Research Project Coordination Unit (BAP: Project Number 14-MYO-82).en_US
dc.identifier.doi10.46770/AS.2018.02.002
dc.identifier.endpage66en_US
dc.identifier.issn0195-5373
dc.identifier.issn2708-521X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85047601673
dc.identifier.scopusqualityQ2
dc.identifier.startpage62en_US
dc.identifier.urihttps://doi.org/10.46770/AS.2018.02.002
dc.identifier.urihttps://hdl.handle.net/11468/19823
dc.identifier.volume39en_US
dc.identifier.wosWOS:000444819900002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherAtomic Spectroscopy Press Ltden_US
dc.relation.ispartofAtomic Spectroscopy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleICP-MS Determination of Lead Levels in Autopsy Liver Samples: An Application in Forensic Medicineen_US
dc.titleICP-MS Determination of Lead Levels in Autopsy Liver Samples: An Application in Forensic Medicine
dc.typeArticleen_US

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