Assessment of methicillin and clindamycin resistance patterns in staphylococcus aureus isolated from a tertiary hospital in Turkey

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dc.contributor.authorTekin A.
dc.contributor.authorDal T.
dc.contributor.authorDeveci O.
dc.contributor.authorTekin R.
dc.contributor.authorAtmaca S.
dc.contributor.authorDayan S.
dc.date.accessioned2024-04-24T18:43:42Z
dc.date.available2024-04-24T18:43:42Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn order to detect the methicillin susceptibility and determine the prevalence of constitutive and inducible clindamycin resistance in Staphylococcus aureus strains, a total of 254 S. aureus isolates, including 139 (54.7%) methicillin-sensitive and 115 (45.3%) methicillin-resistant, were tested for clindamycin and erythromycin by Kirby-Bauer's disk diffusion method. The disk diffusion induction test or D-test was performed on erythromycin-resistant and clindamycin-sensitive strains using the disk diffusion method. The erythromycin-resistant and clindamycin-sensitive strains with a D-shaped zone around the clindamycin disk were considered positive for inducible clindamycin resistance. If a strain was found to be both erythromycin-resistant and clindamycin-resistant, it was considered to have constitutive clindamycin resistance. Overall, ten (3.9%) strains, including two methicillin-resistant S. aureus and eight methicillin-sensitive S. aureus, were found to be erythromycin-resistant and clindamycin-sensitive according to the disk diffusion method and all of these strains showed inducible clindamycin resistance by the D-test method. Constitutive clindamycin resistance was detected in 100 of all MRSA strains. In conclusion, the presence of inducible clindamycin-resistant strains may lead to clindamycin treatment failure in patients with S. aureus infection. The D-test method should be used for antimicrobial susceptibility testing of clindamycin.en_US
dc.identifier.endpage116en_US
dc.identifier.issn1124-9390
dc.identifier.issue2en_US
dc.identifier.pmid23774974en_US
dc.identifier.scopus2-s2.0-84879163638en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://hdl.handle.net/11468/24301
dc.identifier.volume21en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofInfezioni in Medicinaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClindamycinen_US
dc.subjectMethicillinen_US
dc.subjectStaphylococcus Aureusen_US
dc.titleAssessment of methicillin and clindamycin resistance patterns in staphylococcus aureus isolated from a tertiary hospital in Turkeyen_US
dc.title.alternativeDeterminazione dei profili di resistenza a meticillina e clindamicina in isolati di staphylococcus aureus in un ospedale terziario in Turchiaen_US
dc.typeArticleen_US

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