Biochanin A restored the blood-brain barrier in cerebral ischemia-reperfusion in rats

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dc.authoridTuncer, Mehmet Cudi/0000-0001-7317-5467
dc.authoridTUTAL GURSOY, GORKEM/0000-0002-1990-1162
dc.authoridkaraaslanli, abdulmutalip/0009-0005-1046-3484
dc.contributor.authorKaraaslanli, Abdulmutalip
dc.contributor.authorAsir, Firat
dc.contributor.authorGursoy, Gorkem Tutal
dc.contributor.authorTuncer, Mehmet Cudi
dc.date.accessioned2025-02-22T14:08:47Z
dc.date.available2025-02-22T14:08:47Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: Blood-brain barrier is a protective layer that regulates the influx and efflux of biological materials for cerebral tissue. The aim of this study was to investigate the effects of Biochanin A on cerebral histopathology and blood-brain barrier immunohistochemically. METHODS: A total of 24 rats were assigned to three groups: sham, ischemia-reperfusion, and ischemia-reperfusion+Biochanin A. Ischemiareperfusion was performed by occluding the left carotid artery for 2/24 h. Notably, 20 mg/kg Biochanin A was administered to rats for 7 days after ischemia-reperfusion. Blood was collected for malondialdehyde and total oxidant/antioxidant status analysis. Cerebral tissues were processed for histopathology and further for immunohistochemical analysis. RESULTS: Malondialdehyde content with total oxidant status value was significantly increased and total antioxidant status values were significantly decreased in the ischemia-reperfusion group compared with the sham group. Biochanin A treatment significantly improved scores in the ischemiareperfusion+Biochanin A group. The normal histological appearance was recorded in the cerebral sections of the sham group. Degenerated neurons and vascular structures with disrupted integrity of the cerebral cortex were observed after ischemia-reperfusion. Biochanin A alleviated the histopathology in the cerebrum in the ischemia-reperfusion+Biochanin A group. Ischemia-reperfusion injury decreased the expression of blood-brain barrier in the ischemia-reperfusion group compared to the sham group. Administration of Biochanin A upregulated the blood-brain barrier immunoreactivity in the cerebrum by restoring blood-brain barrier. CONCLUSION: Cerebral ischemia-reperfusion caused an increase in oxidative stress and pathological lesions in the cerebrum. Biochanin A treatment restored the adverse effects of ischemia-reperfusion injury by restoring blood-brain barrier.en_US
dc.identifier.doi10.1590/1806-9282.20240025
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue6en_US
dc.identifier.pmid39045961en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20240025
dc.identifier.urihttps://hdl.handle.net/11468/29639
dc.identifier.volume70en_US
dc.identifier.wosWOS:001275495600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAssoc Medica Brasileiraen_US
dc.relation.ispartofRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectBlood-brain barrieren_US
dc.subjectArtery occlusionen_US
dc.subjectAntioxidanten_US
dc.subjectCerebrumen_US
dc.subjectEndotheliumen_US
dc.titleBiochanin A restored the blood-brain barrier in cerebral ischemia-reperfusion in ratsen_US
dc.typeArticleen_US

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