Antibiotic Resistance in Gram-Negative Bacteria Isolated From Blood Cultures

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dc.contributor.authorTemiz, Hakan
dc.contributor.authorTemiz, Sevim
dc.contributor.authorKaya, Safak
dc.contributor.authorCelen, Mustafa Kemal
dc.date.accessioned2024-04-24T17:27:29Z
dc.date.available2024-04-24T17:27:29Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to retrospectively determine the antimicrobial susceptibilities of Gram-negative bacteria isolated from blood cultures of hospitalized patients in 2012. Methods: Antibiotic resistance rates of isolated Gram-negative bacteria were evaluated retrospectively from patients' files. In this study, 106 Gram-negative bacteria isolated from patients' blood culture samples in intensive care units and clinical services were evaluated. Blood samples inoculated into BacT/Alert (R) FA Plus aerobic bottles and were followed in a fully automated blood culture device, BacT/Alert (R) 3D (bioMerieux, Marcy l'Etoile, France). The identification and antibiotic sensitivity tests of the isolated microorganisms were performed using automated VITEK (R) 2 (bioMerieux, Marcy l'Etoile, France) system and the results were evaluated according to the standards of Clinical and Laboratory Standards Institute (CLSI). Results: The most frequently isolated Gram-negative bacteria were Escherichia coli (37.7%), Klebsiella pneumoniae (22.6%), Pseudomonas aeruginosa (12.3%) and Acinetobacter baumannii (13.2%). Extended-spectrum beta-lactamase (ESBL) production was detected in 52.5% of E. coli and 83.3% of K. pneumoniae strains. The most effective antibiotics in vitro for ESBL producing and non-producing strains of both types were found as imipenem and meropenem. Resistance to antibiotics tested in ESBL-producing strains of E. coli was found to be significantly higher than non-ESBL-producing strains (p<0.05). In our study, aminoglycosides, particularly amikacin, was found to be the most effective agents for P. aeruginosa and A. baumannii strains. Imipenem and amikacin were found as most effective antibiotics for the Enterobacter spp. isolated in this study. Conclusions: All institutions should determine their microbial agent and antibiotic resistance profiles and establish their own antibiotic treatment policies and follow current guidelines for empirical antibiotherapy.en_US
dc.identifier.doi10.5152/kd.2014.15
dc.identifier.endpage68en_US
dc.identifier.issn1301-143X
dc.identifier.issn1309-1484
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84940039118
dc.identifier.scopusqualityQ4
dc.identifier.startpage62en_US
dc.identifier.urihttps://doi.org/10.5152/kd.2014.15
dc.identifier.urihttps://hdl.handle.net/11468/19986
dc.identifier.volume27en_US
dc.identifier.wosWOS:000420946700005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherDoc Design Informatics Co Ltden_US
dc.relation.ispartofKlimik Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlood Cultureen_US
dc.subjectAntibiotic Susceptibilityen_US
dc.subjectGram-Negative Bacteriaen_US
dc.titleAntibiotic Resistance in Gram-Negative Bacteria Isolated From Blood Culturesen_US
dc.titleAntibiotic Resistance in Gram-Negative Bacteria Isolated From Blood Cultures
dc.typeArticleen_US

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