Immunohistochemical and Ultrastructural Examination of Changes in the Retina in Diabetic Rats

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dc.contributor.authorTurgut, Fethiye Gulden
dc.contributor.authorOzevren, Huseyin
dc.contributor.authorIrtegun, Sevgi
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:37:31Z
dc.date.available2024-04-24T17:37:31Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To study diabetic retinopathy by the immunohistochemical and ultrastructural examination of changes in the retina in diabetic rats. STUDY DESIGN: We examined the blood-retinal barrier and cell-to-cell connections in diabetic rats by immunohistochemistry and ultrastructural level. Twenty adult male Wistar rats were used in this study. The animals were divided into 2 groups. The control group was fed standard rat chow and drinking water for 8 weeks. Single-dose streptozotocin (55 mg/kg) was dissolved in sodium citrate buffer and administered via intraperitoneal injection to induce diabetes in the diabetes group. The diabetes and control groups were compared for glucose values. RESULTS: The blood glucose concentration in diabetic rats was significantly increased (p< 0.05). Dilation of blood vessels, hemorrhage, and edema were observed in the nerve fibers and ganglion layer. An increase in vascular endothelial growth factor expression was confirmed by Western blot method. E-cadherin-positive cells in the immune junctions between cells in the diabetic retina were observed, weakly staining. CONCLUSION: Ultrastructural analysis of diabetic retinopathy showed that dysfunctionality of photoreceptor cells and vision loss are thought to occur due to mitochondrial degeneration. (Anal Quant Cytopathol Histpathol 2016; 38: 357-363)en_US
dc.identifier.endpage363en_US
dc.identifier.issn0884-6812
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85008700425
dc.identifier.scopusqualityQ4
dc.identifier.startpage357en_US
dc.identifier.urihttps://hdl.handle.net/11468/20983
dc.identifier.volume38en_US
dc.identifier.wosWOS:000398130700005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectDiabetic Retinopathyen_US
dc.subjectE-Cadherinen_US
dc.subjectEyeen_US
dc.subjectRaten_US
dc.subjectRetinaen_US
dc.subjectVegfen_US
dc.titleImmunohistochemical and Ultrastructural Examination of Changes in the Retina in Diabetic Ratsen_US
dc.titleImmunohistochemical and Ultrastructural Examination of Changes in the Retina in Diabetic Rats
dc.typeArticleen_US

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