A detailed study on chemical and biological profile of nine Euphorbia species from Turkey with chemometric approach: Remarkable cytotoxicity of E-fistulasa and promising tannic acid content of E-eriophora

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dc.contributor.authorYener, Ismail
dc.contributor.authorOlmez, Ozge Tokul
dc.contributor.authorErtas, Abdulselam
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.contributor.authorFirat, Mehmet
dc.contributor.authorKandemir, Sevgi Irtegun
dc.contributor.authorOzturk, Mehmet
dc.date.accessioned2024-04-24T16:14:56Z
dc.date.available2024-04-24T16:14:56Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe propose of this study is to investigate the chemical constituents of nine Euphorbia species; namely, E. aleppica, E. eriophora, E. macroclada, E. grisophylla, E. seguieriana subsp. seguieriana, E. craspedia, E. denticulata, E. falcata and E. fistulosa by LC-MS/MS as well as their antioxidant, anticholinesterase, tyrosinase inhibitory, urease inhibitory and cytotoxic activities. Among 59 extracts prepared from the different parts of the mentioned Euphorbia species, E. seguieriana subsp. seguieriana leaf (IC50: 10.41 +/- 0.93 mu g/mL) in lipid peroxidation inhibitory by beta-carotene-linoleic acid assay exhibited the highest activity, while E. grisophylla root in DPPH free radical scavenging (IC50: 0.79 +/- 0.01 mu g/mL), E. grisophylla seed in ABTS cation radical scavenging (IC50: 8.93 +/- 0.02 mu g/mL), E. fistulosa root both in acetyl- and butyryl-cholinesterase inhibitory (53.71 +/- 1.89% and 77.63 +/- 0.60% inhibition, respectively), E. denticulata leaf in urease inhibitory (96.89 +/- 2.00% inhibition), and E. macroclada mixed in tyrosinase inhibitory (86.99 +/- 3.77% inhibition) activities. However in cytotoxic activity studies, E. denticulata against PDF fibroblast cell lines (IC50: 23.04 +/- 0.03 mu g/mL), E. craspedia against HT-29 cancer cell line (IC50: 13.74 +/- 0.02 mu g/mL), E. fistulosa against MCF-7 and DLD-1 cancer cell lines (IC50: 14.04 +/- 0.04 mu g/mL and IC50: 20.23 +/- 0.08 mu g/mL, respectively) indicated quite good activity. According to the LC-MS/MS results, these species were rich in quinic acid, malic acid and tannic acid, rutin, hesperidin and hyperoside. Incidentally, it was found that the E. eriophora possessed very strong irritating potential. A chemometric approach using principal component analysis (PCA) and hierarchical clustering analysis (HCA) techniques were also studied on collected data to reveal the relationship between chemical contents of different parts of these Euphorbia species, and their biological activities, together with regional differences. Overall, these species could be suggested as valuable sources of natural-bioactive agents for developing new functional, pharmacological and health promoting ingredients.en_US
dc.identifier.doi10.1016/j.indcrop.2018.07.007
dc.identifier.endpage453en_US
dc.identifier.issn0926-6690
dc.identifier.issn1872-633X
dc.identifier.scopus2-s2.0-85049868230
dc.identifier.scopusqualityQ1
dc.identifier.startpage442en_US
dc.identifier.urihttps://doi.org/10.1016/j.indcrop.2018.07.007
dc.identifier.urihttps://hdl.handle.net/11468/15534
dc.identifier.volume123en_US
dc.identifier.wosWOS:000447103900050
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofIndustrial Crops and Products
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEuphorbia Speciesen_US
dc.subjectAntioxidant Activityen_US
dc.subjectTyrosinase And Urease Inhibitory Activityen_US
dc.subjectCytotoxic Activityen_US
dc.subjectLc-Ms/Msen_US
dc.subjectChemometryen_US
dc.titleA detailed study on chemical and biological profile of nine Euphorbia species from Turkey with chemometric approach: Remarkable cytotoxicity of E-fistulasa and promising tannic acid content of E-eriophoraen_US
dc.titleA detailed study on chemical and biological profile of nine Euphorbia species from Turkey with chemometric approach: Remarkable cytotoxicity of E-fistulasa and promising tannic acid content of E-eriophora
dc.typeArticleen_US

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