Synthesis of Indole-3-Carboxyaldehyde Thiosemicarbazone Derivatives and Investigation of Antioxidant and Anticholinesterase Properties

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dc.contributor.authorBingül, Murat
dc.date.accessioned2024-04-24T19:11:35Z
dc.date.available2024-04-24T19:11:35Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe synthesis of four indole-3-carboxyaldehyde thiosemicarbazone compounds (3a-d) was achieved viathe Schiff base reaction of the indole-3-carboxyaldehyde and thiosemicarbazides in high yields. Thestructures of thiosemicarbazones 3a and 3b were supported by 1HNMR spectroscopy and confirmedwith the literature data. To the best of our knowledge, our study is the first report for the synthesis ofcompound 3c and literature search revealed that compound 3d was also not fully characterised. Thestructures of compound 3c and 3d were fully characterised by the FT-IR, High Resolution MassSpectrometry (HRMS), 1H and 13CNMR spectroscopy in this work for the first time. Moreover,antioxidant properties of synthesised compounds 3a-d were investigated with the DPPH, ABTS andCUPRAC assays as well as the anticholinesterase properties of designated compounds were determinedby the Acetylcholinesterase (ACh) and Butyrylcholinesterase (BCh) enzyme inhibition assays. Thecompound 3a, 3b and 3d were determined very potent against the ABTS antioxidant assay andcompound 3c was found to be a valuable target molecule for the kinetic measurements to identifymechanism of action in the area of anticholinesterase activity assay.en_US
dc.identifier.doi10.35414/akufemubid.542712
dc.identifier.endpage327en_US
dc.identifier.issn2149-3367
dc.identifier.issue2en_US
dc.identifier.startpage317en_US
dc.identifier.trdizinid312124
dc.identifier.urihttps://doi.org/10.35414/akufemubid.542712
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/312124
dc.identifier.urihttps://hdl.handle.net/11468/28094
dc.identifier.volume19en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofAfyon Kocatepe Üniversitesi Fen ve Mühendislik Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleSynthesis of Indole-3-Carboxyaldehyde Thiosemicarbazone Derivatives and Investigation of Antioxidant and Anticholinesterase Propertiesen_US
dc.titleSynthesis of Indole-3-Carboxyaldehyde Thiosemicarbazone Derivatives and Investigation of Antioxidant and Anticholinesterase Properties
dc.typeArticleen_US

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