Synthesis of Indole-3-Carboxyaldehyde Thiosemicarbazone Derivatives and Investigation of Antioxidant and Anticholinesterase Properties
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Tarih
2019
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The synthesis of four indole-3-carboxyaldehyde thiosemicarbazone compounds (3a-d) was achieved viathe Schiff base reaction of the indole-3-carboxyaldehyde and thiosemicarbazides in high yields. Thestructures of thiosemicarbazones 3a and 3b were supported by 1HNMR spectroscopy and confirmedwith the literature data. To the best of our knowledge, our study is the first report for the synthesis ofcompound 3c and literature search revealed that compound 3d was also not fully characterised. Thestructures of compound 3c and 3d were fully characterised by the FT-IR, High Resolution MassSpectrometry (HRMS), 1H and 13CNMR spectroscopy in this work for the first time. Moreover,antioxidant properties of synthesised compounds 3a-d were investigated with the DPPH, ABTS andCUPRAC assays as well as the anticholinesterase properties of designated compounds were determinedby the Acetylcholinesterase (ACh) and Butyrylcholinesterase (BCh) enzyme inhibition assays. Thecompound 3a, 3b and 3d were determined very potent against the ABTS antioxidant assay andcompound 3c was found to be a valuable target molecule for the kinetic measurements to identifymechanism of action in the area of anticholinesterase activity assay.
Açıklama
Anahtar Kelimeler
Kaynak
Afyon Kocatepe Üniversitesi Fen ve Mühendislik Bilimleri Dergisi
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Scopus Q Değeri
Cilt
19
Sayı
2
