High-field NMR T 2 relaxation mechanism in D2O solutions of albumin

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dc.contributor.authorYilmaz, A.
dc.contributor.authorZengin, B.
dc.date.accessioned2024-04-24T16:02:12Z
dc.date.available2024-04-24T16:02:12Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstract400 MHz NMR T (2) in D2O solutions of albumin and pure D2O were measured at different temperatures. A relation, based on the chemical exchange between bound HDO and non-exchangeable protein protons, was derived theoretically for the contributions of bound HDO [P (b)(1/T (2b))]. A second relation was also derived theoretically by considering spin-rotation interactions between bound HDO and surrounding protein protons. The P (b)(1/T (2b)) values in albumin solutions were then determined by replacing experimental data into the first relation. The values of the 1/T (2) and P (b)(1/T (2b)) in albumin solutions increase linearly with temperature(T), whereas the 1/T (2) in D2O decreases with T. In addition, the spin-rotation correlation times were calculated from the second relation. The dipolar correlation time of albumin was then reproduced from the spin-rotation correlation times for confirmative purposes. In conclusion, the 1/T (2) in albumin solutions with D2O is caused by spin-rotation interactions.en_US
dc.identifier.doi10.1007/s10812-013-9769-5
dc.identifier.endpage340en_US
dc.identifier.issn0021-9037
dc.identifier.issn1573-8647
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84884984531
dc.identifier.scopusqualityQ4
dc.identifier.startpage335en_US
dc.identifier.urihttps://doi.org/10.1007/s10812-013-9769-5
dc.identifier.urihttps://hdl.handle.net/11468/14686
dc.identifier.volume80en_US
dc.identifier.wosWOS:000321642300004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Applied Spectroscopy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProtonen_US
dc.subject400 Mhz Nmren_US
dc.subjectHdoen_US
dc.subjectT-2-Relaxationen_US
dc.subjectSpin Rotationen_US
dc.subjectAlbuminen_US
dc.titleHigh-field NMR T 2 relaxation mechanism in D2O solutions of albuminen_US
dc.titleHigh-field NMR T 2 relaxation mechanism in D2O solutions of albumin
dc.typeArticleen_US

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