The significance of immunoglobulins in cystic fibrosis: Normal or high?

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dc.authorid0000-0002-0297-9772en_US
dc.authorid0000-0002-9232-5982en_US
dc.authorid0000-0001-8780-8122en_US
dc.contributor.authorKan, Ahmet
dc.contributor.authorSavaş, Suat
dc.contributor.authorŞen, Velat
dc.contributor.authorTüre, Mehmet
dc.date.accessioned2023-03-09T08:19:37Z
dc.date.available2023-03-09T08:19:37Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractAim: Cystic fibrosis (CF) is characterized by local and chronic inflammation accompanied by increased neutrophil and macrophage counts, high elastase levels, and inflammatory cytokines due to impaired haemostasis. Changes in immunoglobulin (Ig) levels may occur due to recurrent chronic infections and may be associated with the deterioration of respiratory functions. In this study, we aimed to evaluate the interaction of high Ig levels with respiratory functions and chronic infections in CF. Materials and Methods: The diagnosis of the patients CF was made in accordance with the “National CF Diagnosis and Treatment Guidelines”. The socio-demographic characteristics, Ig values, and the pulmonary function tests were evaluated according to age group. Results: A total of 107 patients were included in this study. The patients’ median age was 65 (6-200) months. It was found that those patients with high IgG (p=0.01) and IgA (p<0.001) values had more moderate-to-severe respiratory function than those with normal values. Also, there was no statistically significant difference when the patients were compared for P. aeruginosa colonization using IgG levels (p=0.51), IgA levels (p=0.16) and IgM levels (p=0.34). Conclusion: Elevated IgG and IgA levels in patients with CF may be an indirect indicator of deterioration in pulmonary function tests. There was no significant difference in IgG, IgA, and IgM levels for P. aeruginosa colonization. We recommend that the results of our study be supported by cohort studies.en_US
dc.identifier.citationKan, A., Savaş, S., Şen, V. ve Türe, M. (2022). The significance of immunoglobulins in cystic fibrosis: Normal or high?. The Journal of Pediatric Research, 9(3), 267-273.en_US
dc.identifier.doi10.4274/jpr.galenos.2022.54533
dc.identifier.endpage273en_US
dc.identifier.issn2147-9445
dc.identifier.issn2587-2478
dc.identifier.issue3en_US
dc.identifier.startpage267en_US
dc.identifier.trdizinid1128394
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1128394
dc.identifier.urihttps://hdl.handle.net/11468/11338
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1128394
dc.identifier.volume9en_US
dc.identifier.wosWOS:000886614100010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorKan, Ahmet
dc.institutionauthorSavaş, Suat
dc.institutionauthorŞen, Velat
dc.institutionauthorTüre, Mehmet
dc.language.isoenen_US
dc.publisherGalenos Yayıncılıken_US
dc.relation.ispartofThe Journal of Pediatric Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCystic fibrosisen_US
dc.subjectImmunoglobulinsen_US
dc.subjectChronic inflammationen_US
dc.subjectRespiratory functionsen_US
dc.titleThe significance of immunoglobulins in cystic fibrosis: Normal or high?en_US
dc.titleThe significance of immunoglobulins in cystic fibrosis: Normal or high?
dc.typeArticleen_US

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