Synthesis, characterization and effect of the fluorine substitution on the redox reactivity and in vitro anticancer behaviors of N-polyfluorophenyl-3,5-di-tert-butylsalicylaldimines and their Cu(II) complexes

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dc.contributor.authorKasumov, V. T.
dc.contributor.authorSuzergoz, F.
dc.contributor.authorSahin, E.
dc.contributor.authorCelik, O.
dc.contributor.authorAslanoglu, M.
dc.date.accessioned2024-04-24T16:15:06Z
dc.date.available2024-04-24T16:15:06Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractA series of new polyfluorinated bis(N-C(6)F(n)H(5-n)3,5-(t)Bu2salicylaidiminato)Cu(11) [n = 2; 2,4-F2C6H3-3,5-DTBS (1), 2,5-F2C6H3-3,5-DTBS (2), 2,6-F2C6H3-3,5-DTBS (3); n = 3; 2,3,4-F3C6H2-3,5-DTBS (4), n= 4; 2,3,5,6-F4C6H-3,5-DTBS (5), n = 5; 2,3,4,5,6-F5C6-3,5-DTBS (6); where 3,5-DTBS is 3,5-(t)Bu(2)salicylaldiminatol with N-polyfluoropheny1-3,5-di-tert-butylsalicylaldi-mines (HL1-HL6) have been synthesized. Their structure, chemical and electrochemical redox-reactivity as well as cytotoxic activity of these compounds were characterized by analytical, spectroscopic (UV/vis, FT-IR, F-19 NMR and EPR), magnetic, CV techniques and MIT assay. The in situ UV/Vis study have shown that the redox behavior of 1-6 and their Cu-phenoxyl radicals (1(center dot+)-6(center dot+) and 1(center dot center dot+)-6(center dot center dot+)) depend on the number and positions of F atoms on the aniline ring as well as of the nature of solvent. The in vitro cytotoxic activity studies of HL1-HL6 and 1-6 against K562 cell lines indicate that the HL1, HL4-HL6 and their corresponding complexes (1, 4-6) exhibited higher cytotoxic activity than HL2, HL3 and their complexes. Compounds 1, 4 and 5 are more cytotoxic than their respective ligands. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipHarra University Research Fund (HUBAK) [712]; Scientific and Technological Research Council of Turkey (TUBITAK) [ARDEB-113Z134]en_US
dc.description.sponsorshipHarra University Research Fund (HUBAK, Project Number 712) and the Scientific and Technological Research Council of Turkey (TUBITAK, Project Number: ARDEB-113Z134) are kindly acknowledged for financial support.en_US
dc.identifier.doi10.1016/j.jfluchem.2014.03.011
dc.identifier.endpage89en_US
dc.identifier.issn0022-1139
dc.identifier.issn1873-3328
dc.identifier.scopus2-s2.0-84899547658
dc.identifier.scopusqualityQ2
dc.identifier.startpage78en_US
dc.identifier.urihttps://doi.org/10.1016/j.jfluchem.2014.03.011
dc.identifier.urihttps://hdl.handle.net/11468/15642
dc.identifier.volume162en_US
dc.identifier.wosWOS:000336827000011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Fluorine Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolyfluorinateden_US
dc.subjectCu(Ii)-Phenoxyl Radicalsen_US
dc.subjectSpectroscopyen_US
dc.subjectAnticanceren_US
dc.titleSynthesis, characterization and effect of the fluorine substitution on the redox reactivity and in vitro anticancer behaviors of N-polyfluorophenyl-3,5-di-tert-butylsalicylaldimines and their Cu(II) complexesen_US
dc.titleSynthesis, characterization and effect of the fluorine substitution on the redox reactivity and in vitro anticancer behaviors of N-polyfluorophenyl-3,5-di-tert-butylsalicylaldimines and their Cu(II) complexes
dc.typeArticleen_US

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