4D-QSAR Study of p56lck Protein Tyrosine Kinase Inhibitory Activity of Flavonoid Derivatives Using MCET Method
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Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Korean Chemical Soc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
A four dimensional quantitative structure activity relationship analysis was applied to a series of 50 flavonoid inhibitors of p56(lck) protein tyrosine kinase by the molecular comparative electron topological method. It was found that the -log (IC50) values of the compounds were highly dependent on the topology, size and electrostatic character of the substituents at seven positions of the flavonoid scaffold in this study. Depending on the negative or positive charge of the groups correctly embedded in these substituents, three-dimensional bio-structure to increase or decrease -log (IC50) values in the training set of 39 compounds was predicted. The test set of 11 compounds was used to evaluate the predictivity of the model. To generate 4D-QSAR model, the defined function groups and pharmacophore used as topological descriptors in the calculation of activity were of sufficient statistical quality (R-2 = 0.72 and Q(2) = 0.69). Ligand docking approach by using Dock 6.0. These compounds include many flavonoid analogs, They were docked onto human families of p56lck PTKs retrieved from the Protein Data Bank, 11kl.pdb.
Açıklama
Anahtar Kelimeler
Drug Design, 4d-Qsar, Flavonoid, Etm, Protein Tyrosine Kinase
Kaynak
Bulletin of The Korean Chemical Society
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
32
Sayı
12
