Importance of curcumin effect and asprosin level on glucose metabolism in diabetic rats

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dc.authorid0000-0002-8691-1504en_US
dc.authorid0000-0002-5546-9653en_US
dc.authorid0000-0003-0108-4149en_US
dc.authorid0000-0003-4585-3712en_US
dc.authorid0000-0002-4461-6822en_US
dc.contributor.authorGökdemir, Gül Şahika
dc.contributor.authorGökdemir, Mehmet Tahir
dc.contributor.authorTaşdemir, Ezel
dc.contributor.authorYokuş, Beran
dc.contributor.authorBaylan, Mukadder
dc.date.accessioned2023-06-20T06:06:41Z
dc.date.available2023-06-20T06:06:41Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümü, Biyokimya Ana Bilim Dalıen_US
dc.description.abstractAsprosin is a new hormone secreted mainly from white adipose tissue. It may be associated with the pathogenesis of obesity, diabetes and some metabolic diseases. The changes in plasma asprosin levels of experimental diabetic rats and the relation of these changes with liver glucose metabolism and some diabetes parameters were investigated, and the effects of metformin, gliclazide or curcumin treatment on plasma asprosin levels were tried. The study was designed as an animal model in diabetic rats The albino rats were divided into five groups. To induce diabetes, a single dose of STZ was injected intraperitoneally. Diabetics rats were treated intragastrically with metformin (D+Metformin group), gliclazide (D+Giliclazide group) or 20 curcumin (D+Curcumin group) for eight weeks. Fasting blood glucose, insulin levels and other parameters were measured. Plasma asporsin levels of untreated diabetic rats increased significantly (P<.001). Although the plasma asprosin levels of diabetic rats treated with the rugs were significantly lower (P<.001). Fasting blood glucose levels of diabetic rats treated with the drugs were found to be remarkably lower than the diabetic control values (P<.001, respectively). There was no significant difference in the insulin levels and HOMA- IR between these three groups. Curcumin treatment provides significant improvements in plasma asprosin level and diabetes parameters. The increase in plasma asprosin level in diabetic rats may be one of the main reasons that facilitate the development of the disease or is responsible for its pathogenesis. Our findings support the idea that curcumin may be an important treatment option for diabetes.en_US
dc.identifier.citationGökdemir, G. Ş., Gökdemir, M. T., Taşdemir, E., Yokuş, B. ve Baylan, M. (2023). Importance of curcumin effect and asprosin level on glucose metabolism in diabetic rats. Medicine Science, 12(1), 167-174.en_US
dc.identifier.doi10.5455/medscience.2022.12.281
dc.identifier.endpage174en_US
dc.identifier.issn2147-0634
dc.identifier.issue1en_US
dc.identifier.startpage167en_US
dc.identifier.trdizinid1176289
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1176289
dc.identifier.urihttps://hdl.handle.net/11468/12087
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1176289
dc.identifier.volume12en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorYokuş, Beran
dc.institutionauthorBaylan, Mukadder
dc.language.isoenen_US
dc.publisherEffect Publishing Agencyen_US
dc.relation.ispartofMedicine Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStreptozotocinen_US
dc.subjectMetforminen_US
dc.subjectGliclazideen_US
dc.subjectCurcuminen_US
dc.subjectRaten_US
dc.titleImportance of curcumin effect and asprosin level on glucose metabolism in diabetic ratsen_US
dc.titleImportance of curcumin effect and asprosin level on glucose metabolism in diabetic rats
dc.typeArticleen_US

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