Investigation of placental hofbauer cells byimmunohistochemistry methods in complicated pregnancies

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dc.authorid0000-0002-9988-9385en_US
dc.authorid0000-0002-0166-9668en_US
dc.authorid0000-0002-6384-9146en_US
dc.authorid0000-0001-8038-0469en_US
dc.authorid0000-0002-4215-1371en_US
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorNergiz, Şebnem
dc.contributor.authorAşır, Fırat
dc.contributor.authorŞahin, Ayşe
dc.contributor.authorAğaçayak, Elif
dc.date.accessioned2022-11-15T12:59:45Z
dc.date.available2022-11-15T12:59:45Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractDevelopment of the placenta without any complication is essential for normal pregnancy.The placenta is a multifunctional organ that plays a vital role in fetal development. Hofbauer cells areone of the most important groups of placental cells. These cells are placental macrophages and have arole in many placental events. The aim of this study is to investigate the placental distribution anddensity of Hofbauer cells and to contribute to the understanding of the causes and pathogenesis ofcomplicated pregnancies. In this study, 60 full-term placentas were divided into 4 equal groups: control,preeclampsia, gestational diabetes (GDM), and ( hemolysis, elevated liver enzymes, low platelet) HELLP group. The placenta was dissected and the samples were fixed 10% neutral buffered formalin.Following routine paraffin wax procedure, 5 µm sections were stained with CD68 for marking Hofbauercells. In immunohistochemical evaluation, Hofbauer cells in villous stroma showed positive CD68expression. Immunostaining Findings: CD68 showed a granular staining pattern in the cytoplasm ofHofbauer cells. The group with the highest CD68 positive cell number was HELLP group and thenumber of cells per cell (1.46 ± 0.25) was significantly different from all groups. CD68 positive cellcount in the placental villus was the highest in HELLP group and the number of Hofbauer cells pervillus was significantly different from the other groups.en_US
dc.identifier.citationNergiz, Y., Nergiz, Ş., Aşır, F., Şahin, A. ve Ağaçayak, E. (2021). Investigation of placental hofbauer cells byimmunohistochemistry methods in complicated pregnancies. Middle East Journal of Science, 7(2), 150-159.en_US
dc.identifier.doi10.51477/mejs.1004971
dc.identifier.endpage159en_US
dc.identifier.issn2618-6136
dc.identifier.issue2en_US
dc.identifier.startpage150en_US
dc.identifier.trdizinid507527
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/507527
dc.identifier.urihttps://hdl.handle.net/11468/10755
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/507527
dc.identifier.volume7en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorNergiz, Yusuf
dc.institutionauthorNergiz, Şebnem
dc.institutionauthorAşır, Fırat
dc.institutionauthorAğaçayak, Elif
dc.language.isoenen_US
dc.publisherInternational Engineering, Science and Education Groupen_US
dc.relation.ispartofMiddle East Journal of Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHofbauer cellsen_US
dc.subjectCD68en_US
dc.subjectPreeclampsiaen_US
dc.subjectHELLP syndromeen_US
dc.subjectGestational diabetesen_US
dc.titleInvestigation of placental hofbauer cells byimmunohistochemistry methods in complicated pregnanciesen_US
dc.titleInvestigation of placental hofbauer cells byimmunohistochemistry methods in complicated pregnancies
dc.typeArticleen_US

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