Factors influencing the prognosis in Braf wild-type metastatic malignant melanoma and the role of novel inflammation indices

dc.contributor.authorEbinc, Senar
dc.contributor.authorKalkan, Ziya
dc.contributor.authorOruc, Zeynep
dc.contributor.authorSezgin, Yasin
dc.contributor.authorUrakci, Zuhat
dc.contributor.authorKucukoner, Mehmet
dc.contributor.authorKaplan, Muhammet Ali
dc.date.accessioned2024-04-24T17:24:31Z
dc.date.available2024-04-24T17:24:31Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and Design: This study aims to investigate the prognostic factors in BRAF wild-type metastatic cutaneous melanoma and the prognostic role of inflammation indices.Materials and Methods: Metastatic BRAF wild-type cutaneous melanoma patients who presented to our clinic between 2011 and 2021 were enrolled. To investigate their prognostic roles, age, gender, performance status, first immunotherapy regimen received by the patient, metastatic sites, and seven inflammation indices [C-reactive protein (CRP)/albumin ratio (CAR), neutrophil lymphocyte ratio (NLR), prognostic nutritional index (PNI), platelet lymphocyte ratio (PLR), systemic immune-inflammation index (SII) and advanced lung cancer inflammation index (ALI) and hemoglobin, albumin levels, lymphocyte and platelet counts (HALP)] were studied.Results: Fourty-seven patients, consisting of 22 (46.8%) females and 25 (53.2%) males, were included in this study. Mean patient age was 54 (18-88) years. In our study, there were 16 (34%) patients with liver metastasis, 17 (36.2%) patients with lung metastasis, and 9 (19.1%) patients with brain metastasis. As immunotherapy, 34 (72.3%) patients had received Nivolumab, while 13 (27.7%) patients had received Ipilimumab therapy. When the relationships of the prognostic variables with overall survival were inspected in univariate and multivariate analyses, brain metastasis was found to be an independent prognostic factor (p=0.02). Lung metastasis approached the threshold of statistical significance in univariate analysis (p=0.09) and liver metastasis in multivariate analysis (p=0.07). The seven inflammation indices examined in the analyses [CAR, NLR, PNI, PLR, SII ALI and HALP] were found to have no prognostic role in both univariate and multivariate analyses.Conclusion: Our study determined that brain metastasis is an independent poor prognostic factor in BRAF wild-type metastatic melanoma. Prognostic roles of the CAR, NLR, PNI, PLR, SII ALI and HALP indices could not be demonstrated.en_US
dc.identifier.doi10.4274/turkderm.galenos.2023.52721
dc.identifier.endpage82en_US
dc.identifier.issn2717-6398
dc.identifier.issn2651-5164
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85175063640
dc.identifier.scopusqualityQ4
dc.identifier.startpage77en_US
dc.identifier.urihttps://doi.org/10.4274/turkderm.galenos.2023.52721
dc.identifier.urihttps://hdl.handle.net/11468/19719
dc.identifier.volume57en_US
dc.identifier.wosWOS:001081128500002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkderm-Turkish Archives of Dermatology and Venerology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBraf Wilden_US
dc.subjectMetastatic Melanomaen_US
dc.subjectInflammation Indicesen_US
dc.subjectPrognosisen_US
dc.titleFactors influencing the prognosis in Braf wild-type metastatic malignant melanoma and the role of novel inflammation indicesen_US
dc.titleFactors influencing the prognosis in Braf wild-type metastatic malignant melanoma and the role of novel inflammation indices
dc.typeArticleen_US

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