Retinal microvascular changes in patients with familial mediterranean fever: a study based on optical coherence tomography angiography

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dc.contributor.authorErdem, Seyfettin
dc.contributor.authorKarahan, Mine
dc.contributor.authorAva, Sedat
dc.contributor.authorDursun, Mehmet Emin
dc.contributor.authorCevik, Figen Ceylan
dc.contributor.authorOzkul, Emin
dc.contributor.authorKeklikci, Ugur
dc.date.accessioned2024-04-24T17:28:11Z
dc.date.available2024-04-24T17:28:11Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: In this study, we aimed to show whether a difference exists between retinal and choroidal microcirculation findings between patients with familial Mediterranean fever and healthy controls. Methods: Thirty-two patients with familial Mediterranean fever and 30 healthy controls were included in the study. All the patients underwent a complete ophthalmologic examination, including best-corrected visual acuity and intraocular pressure measurement. The AngioVue optical coherence tomography angiography device (Optovue, Fremont, CA) with split-spectrum amplitude-decorrelation angiography was used to evaluate and examine the retinal microvascular structure. Three-dimensional en face Optical coherence tomography angiography images were obtained by examining the macula using the 3 x 3 mm scanning protocol in the Angio Retina mode and the optic nerve using the 3 x 3 mm scanning protocol in the Angio Disk mode. All the patients' right eyes were examined. Results: A total of 62 subjects were included in the study, of whom 32 (53.3%) were female and 30 (46.7%) were male. No statistically significant difference was found between the two groups in terms of optic nerve head or radial peripapillary capillary vessel density. On examination, the superficial capillary plexuses were statistically similar between the two groups, but the deep capillary plexus vessel density in the parafovea, superior hemi, temporal, and superior areas were significantly lower in the patients with familial Mediterranean fever. Conclusions: We found that the capillary plexus vessel density was significantly lower in the parafovea, superior hemi, temporal, and superior regions in the patients with familial Mediterranean fever than in the control group. Therefore, OCTA, a noninvasive study, may be useful for understanding the systemic effects of familial Mediterranean fever.en_US
dc.identifier.doi10.5935/0004-2749.2022-0038
dc.identifier.endpage388en_US
dc.identifier.issn0004-2749
dc.identifier.issn1678-2925
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85135421413
dc.identifier.scopusqualityQ3
dc.identifier.startpage382en_US
dc.identifier.urihttps://doi.org/10.5935/0004-2749.2022-0038
dc.identifier.urihttps://hdl.handle.net/11468/20356
dc.identifier.volume85en_US
dc.identifier.wosWOS:000837218600010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherConsel Brasil Oftalmologiaen_US
dc.relation.ispartofArquivos Brasileiros De Oftalmologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOptical Coherence Tomography Angiographyen_US
dc.subjectFamilial Mediterranean Feveren_US
dc.subjectRetinal Microcirculationen_US
dc.subjectSuperficial Plexusen_US
dc.subjectDeep Vascular Capillary Plexusen_US
dc.titleRetinal microvascular changes in patients with familial mediterranean fever: a study based on optical coherence tomography angiographyen_US
dc.titleRetinal microvascular changes in patients with familial mediterranean fever: a study based on optical coherence tomography angiography
dc.typeArticleen_US

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