Hipoksik iskemik ensefalopatide N-terminal pro brain natriüretikpeptid ve troponin I düzeylerinin önemi
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Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Dicle Üniversitesi Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Hipoksikiskemikensefalopati (HİE), perinatal dönemde hipoksiye bağlı olarak görülen ağır morbidite ve mortalite
ile sonuçlanabilen klinik bir durumdur. Bu çalışmanın amacı, hipoksik iskemik ensefalopatide kardiyak
biyomarkerlerden N-Terminal pro Brain Natriüretik Peptid (NTproBNP) ve Troponin I’nın rolünü değerlendirmektir.
Yöntemler: Bu çalışmada, Ocak 2019 ve Mayıs 2021 tarihleri arasında Yenidoğan Yoğun Bakım Ünitesinde HİE tanısı ile
takip ve tedavileri yapılmış olan hastaların Troponin I ve NTproBNP düzeyleri geriye dönük olarak incelendi.
Bulgular: Bu çalışma %44,5 (45)’i kız ve %55.5(56)’sı erkek olmak üzere 101 olgudan oluştu. Normal spontan vajinal
yol ile doğum oranı %57,8 (63) iken Sezaryenle doğum oranı %42,2 (46) idi. Olgularda HİE evre 1 oranı %31.7 (32), HİE
evre2 oranı %31,7 (32) ve HİE evre 3 oranı%36,6 (37) olarak bulundu. Ortalama doğum ağırlığı 3139.95±499.02 g,
ortalama gestasyon haftası 38.39±1.69 hafta bulundu. NTproBNP; ortalama 10099.49±12023.03 pg/mL ve Troponin I;
122.575±188.5287 ng/L bulundu. Hipoksik iskemik ensefalopatinin şiddetinin artması ile Troponin I arasında
istatistiksel olarak anlamlı bir fark bulunurken, NTproBNP ile HİE’nin şiddeti arasında herhangi bir farklılık bulunmadı.
Sonuç: Yenidoğan HİE’li bebeklerde NTproBNP ve Troponin I düzeylerinde artış vardır. Ayrıca, Troponin I düzeyleri ile
yenidoğan hipoksik iskemik ensefalopati şiddeti arasında anlamlı ilişki olduğu bulundu.
Objective: Hypoxic ischemic encephalopathy (HIE) is a clinical condition that can result in severe morbidity and mortality due to hypoxia in the perinatal period. The aim of this study is to evaluate the role of cardiac biomarkers NTerminal pro Brain Natriuretic Peptide (NTproBNP) and Troponin I in hypoxic ischemic encephalopathy. Methods: In this study, Troponin I and NTproBNP levels of patients who were followed up and treated with the diagnosis of HIE in the Neonatal Intensive Care Unit between January 2019 and May 2021 were evaluated retrospectively. Results: This study consisted of 101 subjects, 44.5% (45) female and 55.5% (56%) male. While the rate of normal spontaneous vaginal delivery was 57.8% (63), the rate of cesarean delivery was 42.2% (46). In the cases, the rate of HIE stage 1 was 31.7% (32), the rate of HIE stage 2 was 31.7% (32) and the rate of HIE stage 3 was 36.6% (37). Mean birth weight was 3139.95±499.02 g, mean gestational week was 38.39±1.69 weeks. NTproBNP; mean 10099.49±12023.03 pg/mL and Troponin I; 122.575±188.5287 ng/L was found. While there was a statistically significant difference between the increase in the severity of hypoxic ischemic encephalopathy and Troponin I, there was no difference between the severity of NTproBNP and HIE. Conclusion: There is an increase in NTproBNP and Troponin I levels in infants with neonatal HIE. In addition, a significant correlation was found between Troponin I levels and the severity of neonatal hypoxic ischemic encephalopathy.
Objective: Hypoxic ischemic encephalopathy (HIE) is a clinical condition that can result in severe morbidity and mortality due to hypoxia in the perinatal period. The aim of this study is to evaluate the role of cardiac biomarkers NTerminal pro Brain Natriuretic Peptide (NTproBNP) and Troponin I in hypoxic ischemic encephalopathy. Methods: In this study, Troponin I and NTproBNP levels of patients who were followed up and treated with the diagnosis of HIE in the Neonatal Intensive Care Unit between January 2019 and May 2021 were evaluated retrospectively. Results: This study consisted of 101 subjects, 44.5% (45) female and 55.5% (56%) male. While the rate of normal spontaneous vaginal delivery was 57.8% (63), the rate of cesarean delivery was 42.2% (46). In the cases, the rate of HIE stage 1 was 31.7% (32), the rate of HIE stage 2 was 31.7% (32) and the rate of HIE stage 3 was 36.6% (37). Mean birth weight was 3139.95±499.02 g, mean gestational week was 38.39±1.69 weeks. NTproBNP; mean 10099.49±12023.03 pg/mL and Troponin I; 122.575±188.5287 ng/L was found. While there was a statistically significant difference between the increase in the severity of hypoxic ischemic encephalopathy and Troponin I, there was no difference between the severity of NTproBNP and HIE. Conclusion: There is an increase in NTproBNP and Troponin I levels in infants with neonatal HIE. In addition, a significant correlation was found between Troponin I levels and the severity of neonatal hypoxic ischemic encephalopathy.
Açıklama
Anahtar Kelimeler
Hipoksik iskemik ensefalopati, Troponin I, NTproBNP, Hypoxic ischemic encephalopathy
Kaynak
Dicle Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
48
Sayı
4
Künye
Değer, İ., Ertuğrul, S., Yılmaz, S. T. ve Türe, M. (2021). Hipoksik iskemik ensefalopatide N-terminal pro brain natriüretikpeptid ve troponin I düzeylerinin önemi. Dicle Tıp Dergisi, 48(4), 874-880.
