Proton NMR Relaxation in Albumin Solution Doped with Mn(II)

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dc.contributor.authorYilmaz, A.
dc.contributor.authorKoylu, M. Z.
dc.contributor.authorUysal, E.
dc.date.accessioned2024-04-24T16:01:57Z
dc.date.available2024-04-24T16:01:57Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study is to obtain further information about the source of proton relaxation in the Mn(II)-human serum albumin complex. For this purpose, proton relaxation rates in albumin solutions 1/T(1) and 1/T(2) were measured versus increasing amounts of manganese [Mn(t)]. The fractions of manganese bound to albumin [Mn(b)] and free manganese [Mn(f)] were then determined from proton relaxation rate enhancement data. Paramagnetic contributions of bound manganese to the observed relaxation rates (1/T(1p)*)(b) and (1/T(2p)*)(b) were also determined. Finally, the (1/T(2p)*)(b)/(1/T(1p)*)(b) ratio was used in a derived equation to estimate an effective correlation time tau. Mean tau value of the complex was found to be in the order of 3 ns, while the hydration number of bound manganese q was estimated to be about 4. The 1/tau was found to be the sum of the inverse values of rotational correlation time 1/tau(r), mean residence time of water in hydration spheres of the complex 1/tau(m), and longitudinal electronic relaxation time of manganese 1/tau(s) in the complex. In conclusion, the relaxation mechanism in albumin solutions containing Mn(II) can be interpreted through dipolar and scalar interactions modulated by tau(r), tau(m) and tau(s). This analysis enables one to get reasonable figures for the tau(r) and q of Mn(II) in albumin solution.en_US
dc.identifier.doi10.1007/s00723-009-0189-x
dc.identifier.endpage612en_US
dc.identifier.issn0937-9347
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-65749088450
dc.identifier.scopusqualityQ3
dc.identifier.startpage601en_US
dc.identifier.urihttps://doi.org/10.1007/s00723-009-0189-x
dc.identifier.urihttps://hdl.handle.net/11468/14531
dc.identifier.volume35en_US
dc.identifier.wosWOS:000266072400010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofApplied Magnetic Resonance
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleProton NMR Relaxation in Albumin Solution Doped with Mn(II)en_US
dc.titleProton NMR Relaxation in Albumin Solution Doped with Mn(II)
dc.typeArticleen_US

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