Could the appropriate anti-diabetic therapy be mixed insulin in dialysis patients?

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dc.contributor.authorDemircan, Vehbi
dc.contributor.authorYildirim, Yasar
dc.contributor.authorAydin, Emre
dc.contributor.authorKara, Ali Veysel
dc.contributor.authorAydin, Fatma Yilmaz
dc.contributor.authorYilmaz, Zulfukar
dc.contributor.authorKadiroglu, Ali Kemal
dc.date.accessioned2024-04-24T16:10:37Z
dc.date.available2024-04-24T16:10:37Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground A good glycemic regulation should be provided to reduce mortality and morbidity in patients with end-stage renal failure due to diabetes mellitus. However, the use of insulin therapies in patients with renal failure is troublesome due to the increased rate of side effects. In our study, we investigated the frequency of hypoglycemia and its symptoms in patient groups receiving intensive and mixed insulin therapies. Materials and methods This prospective study included 89 hemodialysis patients with DM-related stage 5 chronic kidney disease who were followed up in a nephrology clinic of a university hospital between January 2013 and August 2015. Our study group was divided into two groups as those receiving intensive insulin therapy and mixed insulin therapy. Group 1 and group 2 consisted of 46 patients and 43 patients, respectively. Hypoglycemia (glucose < 70 mg/dl) was investigated in patients with HbA1c levels that decreased below 7% after treatment, and the symptoms were evaluated according to the hypoglycemic scale. The results between the groups were evaluated using chi-square and Student's t test Results A total of 89 patients were included in the study. HbA1c was 6.83% in the group receiving intensive insulin therapy and 6.95% in the group receiving mixed insulin therapy (p > 0.05). Hypoglycemia was detected in 27 patients (58.7%) in the intensive insulin therapy group and 14 patients (32.6%) in the mixed insulin therapy group. There was a significant level of hypoglycemia in the group receiving intensive insulin therapy (p < 0.05). In our study, the group receiving intensive insulin therapy had higher frequency and severity of common hypoglycemia symptoms such as confusion, sweating, weakness, dysphasia, palpitations, blurred vision, and feeling hungry. Conclusion There was a higher frequency of hypoglycemia under intensive insulin therapy in patients undergoing dialysis due to chronic kidney failure, which suggests that mixed insulin therapy is the ideal treatment to avoid hypoglycemia in this group of patients.en_US
dc.identifier.doi10.1007/s13410-020-00892-7
dc.identifier.endpage292en_US
dc.identifier.issn0973-3930
dc.identifier.issn1998-3832
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85095794778
dc.identifier.scopusqualityQ3
dc.identifier.startpage288en_US
dc.identifier.urihttps://doi.org/10.1007/s13410-020-00892-7
dc.identifier.urihttps://hdl.handle.net/11468/14969
dc.identifier.volume41en_US
dc.identifier.wosWOS:000588251800004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofInternational Journal of Diabetes in Developing Countries
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectHypoglycemiaen_US
dc.subjectInsulin Therapyen_US
dc.subjectDialysisen_US
dc.subjectKidney Failureen_US
dc.titleCould the appropriate anti-diabetic therapy be mixed insulin in dialysis patients?en_US
dc.titleCould the appropriate anti-diabetic therapy be mixed insulin in dialysis patients?
dc.typeArticleen_US

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