Antibiotic Susceptibility of Microorganisms Grown in Tracheal Aspirate Cultures of Pediatric Intensive Care Patients

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dc.contributor.authorOrhan, Ozhan
dc.contributor.authorYilmaz, Kamil
dc.contributor.authorPirinccioglu, Ayfer Gozu
dc.contributor.authorSolmaz, Murat
dc.contributor.authorKarakoc, Ferhat
dc.date.accessioned2024-04-24T17:28:26Z
dc.date.available2024-04-24T17:28:26Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground Microorganisms proliferating in the hospital setting cause infections with high morbidity and mortality rates. In intensive care units (ICUs), the rates of antibiotic resistance and microorganisms grown in cultures may vary by time period. Antibiotic sensitivity must be known for a correct empirical treatment approach. This study aimed to investigate the distribution and antibiotic resistance profiles of pathogenic microorganisms isolated from tracheal aspirate samples in the ICU. Methodology This study enrolled 100 tracheostomized patients aged one month to 18 years, regardless of gender, who were followed in the ICU of Dicle University for more than 72 hours. Medical data were retrospectively evaluated from the medical records. Care was taken to collect samples before changing antibiotics. Antibiotherapy was continued until after culture antibiogram results were obtained, or empirical antibiotic therapy was started by giving consideration to the potential source in patients with a suspected infection. Results An analysis of the tracheal aspirate culture samples of the patients showed that Pseudomonas aeruginosa (54%), Acinetobacter baumannii (16%), and Staphylococcus aureus (8%) were the most common pathogens. An analysis of the culture antibiogram results of the tracheal aspirate samples obtained from the entire study population showed that P. aeruginosa was 100% resistant against vancomycin, clindamycin, and teicoplanin, but highly sensitive to colistin and amikacin. A. baumannii was highly resistant to almost all antibiotics but showed no resistance against colistin. Carbapenems being frequently preferred for cases where empirical therapy should be initiated for ICU infections can be one of the reasons for a high carbapenem resistance rate in our hospital. Conclusions We believe that starting empirical therapy with colistin when infections caused by Pseudomonas and Acinetobacter are suspected may be an appropriate initial therapy until culture antibiogram results become available. Microbiological data are crucial for a correct empirical treatment approach. In this way, intensive antibiotic usage and subsequent high antibiotic resistance can be adequately controlled.en_US
dc.identifier.doi10.7759/cureus.26934
dc.identifier.issn2168-8184
dc.identifier.issue7en_US
dc.identifier.pmid35989826
dc.identifier.urihttps://doi.org/10.7759/cureus.26934
dc.identifier.urihttps://hdl.handle.net/11468/20435
dc.identifier.volume14en_US
dc.identifier.wosWOS:000864216700005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCureus Incen_US
dc.relation.ispartofCureus Journal of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntensive Care Uniten_US
dc.subjectPediatricen_US
dc.subjectEmpirical Therapyen_US
dc.subjectDrug Resistanceen_US
dc.subjectTracheal Aspirateen_US
dc.titleAntibiotic Susceptibility of Microorganisms Grown in Tracheal Aspirate Cultures of Pediatric Intensive Care Patientsen_US
dc.titleAntibiotic Susceptibility of Microorganisms Grown in Tracheal Aspirate Cultures of Pediatric Intensive Care Patients
dc.typeArticleen_US

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