Synthesis and characterization of new branched magnetic nanocomposite for loading and release of topotecan anti-cancer drug

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dc.authorid0000-0001-7555-2481en_US
dc.contributor.authorTarhan, Tuba
dc.contributor.authorTural, Bilsen
dc.contributor.authorTural, Servet
dc.date.accessioned2021-09-13T05:58:55Z
dc.date.available2021-09-13T05:58:55Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Ziya Gökalp Eğitim Fakültesi, Matematik ve Fen Bilimleri Eğitimi Bölümüen_US
dc.description.abstractThe purpose of this study is to synthesize the new branched magnetic nanocomposite to carry the therapeutic agents and bio-macromolecules. Although topotecan (TPT) has significant antitumor activity to lung, ovarian, breast, pancreas, and stomach cancers, lactone ring opening causes a reduction in cytotoxic activity and severe side effects in physiological conditions. In order to contribute to the removal of the handicap (lactone ring opening), magnetic dextran branched with NαNα-Bis (carboxymethyl)-l-lysine hydrate (NTA) nanoparticles (MD3) were prepared. The characterization of the resulting MD3 material was done by using multi-pronged analyses. The stability and release of TPT with synthesized and characterized new material of the MD3 was studied using various essential factors like concentration, dosage, pH, and time. The entrapment efficiency and loading capacity of TPT onto MD3 was calculated as 32.2% and 1.44 mg/g, respectively, at pH 5. Release studies were performed with drug-loaded MD3 at different pH values. It was seen that the best release was obtained at the cancerous site pH. Initial drug concentration was measured as 0.118 mM. The loaded drug concentration was calculated as 0.0380 mM at pH 5 and 0.00092 mM of drug was released after 90 min at pH 5.8. Percentage released of drug was found as 2.42% during 90 min. [Figure not available: see fulltext.].en_US
dc.identifier.citationTarhan, T., Tural, B. ve Tural, S. (2019). Synthesis and characterization of new branched magnetic nanocomposite for loading and release of topotecan anti-cancer drug. Journal of Analytical Science and Technology, 10(1), 30.en_US
dc.identifier.doi10.1186/s40543-019-0189-x
dc.identifier.issn2093-3134
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85071912299
dc.identifier.scopusqualityQ2
dc.identifier.startpage30en_US
dc.identifier.urihttps://jast-journal.springeropen.com/articles/10.1186/s40543-019-0189-x
dc.identifier.urihttps://hdl.handle.net/11468/7522
dc.identifier.volume10en_US
dc.identifier.wosWOS:000484442500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTural, Bilsen
dc.institutionauthorTural, Servet
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Analytical Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDrug nanocarrieren_US
dc.subjectDrug releaseen_US
dc.subjectMagnetic nanocompositeen_US
dc.subjectMagnetic targetingen_US
dc.subjectNew branched dextranen_US
dc.subjectTopotecanen_US
dc.titleSynthesis and characterization of new branched magnetic nanocomposite for loading and release of topotecan anti-cancer drugen_US
dc.titleSynthesis and characterization of new branched magnetic nanocomposite for loading and release of topotecan anti-cancer drug
dc.typeArticleen_US

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